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Pancreatic Stellate Cells and Pancreatic Cancer Cells: An Unholy Alliance

¹ Pancreatic Research Group, South Western Sydney Clinical School and ² School of Medical Sciences/Pathology, The University of New South Wales and Sydney, Australia

Requests for reprints: Minoti V. Apte, South Western Sydney Clinical School, Room 505, Level 5, Wallace Wurth Building, The University of New South Wales, Sydney, NSW 2052 Australia. Phone: 61-2-93858273; Fax: 61-2-93851389; E-mail: m.apte{at}unsw.edu.au.

Key Words: pancreatic cancer • stromal reaction • stellate cells • tumor growth • metastasis

Pancreatic cancer—a tumor displaying a particularly abundant stromal reaction—is notorious for its poor prognosis. Recent studies, via newly developed orthotopic models, provide compelling evidence of an important role for pancreatic stellate cells (PSC) in pancreatic cancer progression. Characterization of the mechanisms mediating PSC-cancer interactions will lead to the development of much needed alternative therapeutic approaches to improve disease outcome. [Cancer Res 2008;68(19):7707–10]