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[Cancer Research 66, 4549-4552, May 1, 2006]
© 2006 American Association for Cancer Research

Reviews

Exploring a New Twist on Tumor Metastasis

Jing Yang1, Sendurai A. Mani1 and Robert A. Weinberg1,2

1 Whitehead Institute for Biomedical Research, Cambridge Center and 2 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts

Requests for reprints: Robert A. Weinberg, Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142. Phone: 617-258-5176; E-mail: weinberg{at}wi.mit.edu.

Unraveling the genetic programs that drive -metastasis may offer insights into how to limit or prevent this deadly aspect of cancer progression. Our recent studies indicate that tumor cell metastasis involves the activity of the transcription factor, Twist, which regulates epithelial-mesenchymal transition and early embryonic morphogenesis. Here, we review the Twist signaling pathway during normal development and discuss how the transcription factor Twist and the epithelial-mesenchymal transition program impinge their biological functions during tumor metastasis. (Cancer Res 2006; 66(9): 4549-52)




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2006 by the American Association for Cancer Research.