Cancer Research 09 AM Call for Abstracts SU2C
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Data
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Iorio, M. V.
Right arrow Articles by Croce, C. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iorio, M. V.
Right arrow Articles by Croce, C. M.
[Cancer Research 65, 7065-7070, August 15, 2005]
© 2005 American Association for Cancer Research

Priority Reports

MicroRNA Gene Expression Deregulation in Human Breast Cancer

Marilena V. Iorio1, Manuela Ferracin2, Chang-Gong Liu1, Angelo Veronese2, Riccardo Spizzo2, Silvia Sabbioni2, Eros Magri2, Massimo Pedriali2, Muller Fabbri1, Manuela Campiglio3, Sylvie Ménard3, Juan P. Palazzo4, Anne Rosenberg5, Piero Musiani6, Stefano Volinia1, Italo Nenci2, George A. Calin1, Patrizia Querzoli2, Massimo Negrini2 and Carlo M. Croce1

1 Comprehensive Cancer Center, Ohio State University, Columbus, Ohio; 2 Dipartimento di Medicina Sperimentale e Diagnostica, e Centro Interdipartimentale per la Ricerca sul Cancro, Università di Ferrara, Ferrara, Italy; 3 Molecular Targeting Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy; Departments of 4 Pathology, Anatomy and Cell Biology and 5 Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania; and 6 Ce.S.I. Aging Research Center, Chieti, Italy

Requests for reprints: Carlo M. Croce, Comprehensive Cancer Center, Ohio State University, Room 445C, Wiseman Hall, 400 12th Avenue, Columbus, OH 43210. Phone: 614-292-3063; Fax: 614-292-3312; E-mail: Carlo.Croce{at}osumc.edu.

MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation. Their aberrant expression may be involved in human diseases, including cancer. Indeed, miRNA aberrant expression has been previously found in human chronic lymphocytic leukemias, where miRNA signatures were associated with specific clinicobiological features. Here, we show that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer. The overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated miRNAs being mir-125b, mir-145, mir-21, and mir-155. Results were confirmed by microarray and Northern blot analyses. We could identify miRNAs whose expression was correlated with specific breast cancer biopathologic features, such as estrogen and progesterone receptor expression, tumor stage, vascular invasion, or proliferation index.




This article has been cited by other articles:


Home page
 BloodHome page
R. Dai, R. A. Phillips, Y. Zhang, D. Khan, O. Crasta, and S. A. Ahmed
Suppression of LPS-induced Interferon-{gamma} and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulation
Blood, December 1, 2008; 112(12): 4591 - 4597.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
W. Kong, H. Yang, L. He, J.-j. Zhao, D. Coppola, W. S. Dalton, and J. Q. Cheng
MicroRNA-155 Is Regulated by the Transforming Growth Factor {beta}/Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA
Mol. Cell. Biol., November 15, 2008; 28(22): 6773 - 6784.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. L. Bearfoot, D. Y.H. Choong, K. L. Gorringe, and I. G. Campbell
Genetic Analysis of Cancer-Implicated MicroRNA in Ovarian Cancer
Clin. Cancer Res., November 15, 2008; 14(22): 7246 - 7250.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-J. Zhao, J. Lin, H. Yang, W. Kong, L. He, X. Ma, D. Coppola, and J. Q. Cheng
MicroRNA-221/222 Negatively Regulates Estrogen Receptor{alpha} and Is Associated with Tamoxifen Resistance in Breast Cancer
J. Biol. Chem., November 7, 2008; 283(45): 31079 - 31086.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
L.-X. Yan, X.-F. Huang, Q. Shao, M.-Y. Huang, L. Deng, Q.-L. Wu, Y.-X. Zeng, and J.-Y. Shao
MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis
RNA, November 1, 2008; 14(11): 2348 - 2360.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. E. Miller, K. Ghoshal, B. Ramaswamy, S. Roy, J. Datta, C. L. Shapiro, S. Jacob, and S. Majumder
MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by Targeting p27Kip1
J. Biol. Chem., October 31, 2008; 283(44): 29897 - 29903.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
C. Taccioli, E. Fabbri, R. Visone, S. Volinia, G. A. Calin, L. Y. Fong, R. Gambari, A. Bottoni, M. Acunzo, J. Hagan, et al.
UCbase & miRfunc: a database of ultraconserved sequences and microRNA function
Nucleic Acids Res., October 22, 2008; (2008) gkn702v1.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. D. N. Reddy, K. Ohshiro, S. K. Rayala, and R. Kumar
MicroRNA-7, a Homeobox D10 Target, Inhibits p21-Activated Kinase 1 and Regulates Its Functions
Cancer Res., October 15, 2008; 68(20): 8195 - 8200.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. J. Chin, E. Ratner, S. Leng, R. Zhai, S. Nallur, I. Babar, R.-U. Muller, E. Straka, L. Su, E. A. Burki, et al.
A SNP in a let-7 microRNA Complementary Site in the KRAS 3' Untranslated Region Increases Non-Small Cell Lung Cancer Risk
Cancer Res., October 15, 2008; 68(20): 8535 - 8540.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Papagiannakopoulos, A. Shapiro, and K. S. Kosik
MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells
Cancer Res., October 1, 2008; 68(19): 8164 - 8172.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. Markou, E. G. Tsaroucha, L. Kaklamanis, M. Fotinou, V. Georgoulias, and E. S. Lianidou
Prognostic Value of Mature MicroRNA-21 and MicroRNA-205 Overexpression in Non-Small Cell Lung Cancer by Quantitative Real-Time RT-PCR
Clin. Chem., October 1, 2008; 54(10): 1696 - 1704.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Yamakuchi, M. Ferlito, and C. J. Lowenstein
miR-34a repression of SIRT1 regulates apoptosis
PNAS, September 9, 2008; 105(36): 13421 - 13426.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. A. Foekens, A. M. Sieuwerts, M. Smid, M. P. Look, V. de Weerd, A. W. M. Boersma, J. G. M. Klijn, E. A. C. Wiemer, and J. W. M. Martens
Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer
PNAS, September 2, 2008; 105(35): 13021 - 13026.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
W. Tam
The Emergent Role of MicroRNAs in Molecular Diagnostics of Cancer
J. Mol. Diagn., September 1, 2008; 10(5): 411 - 414.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Ambs, R. L. Prueitt, M. Yi, R. S. Hudson, T. M. Howe, F. Petrocca, T. A. Wallace, C.-G. Liu, S. Volinia, G. A. Calin, et al.
Genomic Profiling of MicroRNA and Messenger RNA Reveals Deregulated MicroRNA Expression in Prostate Cancer
Cancer Res., August 1, 2008; 68(15): 6162 - 6170.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Kondo, T. Toyama, H. Sugiura, Y. Fujii, and H. Yamashita
miR-206 Expression Is Down-regulated in Estrogen Receptor {alpha}-Positive Human Breast Cancer
Cancer Res., July 1, 2008; 68(13): 5004 - 5008.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Nie, M. Gomez, P. Landgraf, J.-F. Garcia, Y. Liu, L. H.C. Tan, A. Chadburn, T. Tuschl, D. M. Knowles, and W. Tam
MicroRNA-Mediated Down-Regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg Cells: A Potential Pathogenetic Lesion in Hodgkin Lymphomas
Am. J. Pathol., July 1, 2008; 173(1): 242 - 252.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
O. Kovalchuk, J. Filkowski, J. Meservy, Y. Ilnytskyy, V. P. Tryndyak, V. F. Chekhun, and I. P. Pogribny
Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
Mol. Cancer Ther., July 1, 2008; 7(7): 2152 - 2159.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
K. Chen, F. Song, G. A. Calin, Q. Wei, X. Hao, and W. Zhang
Polymorphisms in microRNA targets: a gold mine for molecular epidemiology
Carcinogenesis, July 1, 2008; 29(7): 1306 - 1311.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. Brendle, H. Lei, A. Brandt, R. Johansson, K. Enquist, R. Henriksson, K. Hemminki, P. Lenner, and A. Forsti
Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker
Carcinogenesis, July 1, 2008; 29(7): 1394 - 1399.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Kim, U. J. Lee, M. N. Kim, E.-J. Lee, J. Y. Kim, M. Y. Lee, S. Choung, Y. J. Kim, and Y.-C. Choi
MicroRNA miR-199a* Regulates the MET Proto-oncogene and the Downstream Extracellular Signal-regulated Kinase 2 (ERK2)
J. Biol. Chem., June 27, 2008; 283(26): 18158 - 18166.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
Q. Yin, J. McBride, C. Fewell, M. Lacey, X. Wang, Z. Lin, J. Cameron, and E. K. Flemington
MicroRNA-155 Is an Epstein-Barr Virus-Induced Gene That Modulates Epstein-Barr Virus-Regulated Gene Expression Pathways
J. Virol., June 1, 2008; 82(11): 5295 - 5306.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
A. Hudder and R. F. Novak
miRNAs: Effectors of Environmental Influences on Gene Expression and Disease
Toxicol. Sci., June 1, 2008; 103(2): 228 - 240.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Jongen-Lavrencic, S. M. Sun, M. K. Dijkstra, P. J. M. Valk, and B. Lowenberg
MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia
Blood, May 15, 2008; 111(10): 5078 - 5085.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. N. Nikiforova, G. C. Tseng, D. Steward, D. Diorio, and Y. E. Nikiforov
MicroRNA Expression Profiling of Thyroid Tumors: Biological Significance and Diagnostic Utility
J. Clin. Endocrinol. Metab., May 1, 2008; 93(5): 1600 - 1608.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J.-W. Lee, C. H. Choi, J.-J. Choi, Y.-A. Park, S.-J. Kim, S. Y. Hwang, W. Y. Kim, T.-J. Kim, J.-H. Lee, B.-G. Kim, et al.
Altered MicroRNA Expression in Cervical Carcinomas
Clin. Cancer Res., May 1, 2008; 14(9): 2535 - 2542.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. J. Nam, H. Yoon, S. W. Kim, H. Kim, Y. T. Kim, J. H. Kim, J. W. Kim, and S. Kim
MicroRNA Expression Profiles in Serous Ovarian Carcinoma
Clin. Cancer Res., May 1, 2008; 14(9): 2690 - 2695.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Sengupta, J. A. den Boon, I-H. Chen, M. A. Newton, S. A. Stanhope, Y.-J. Cheng, C.-J. Chen, A. Hildesheim, B. Sugden, and P. Ahlquist
MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins
PNAS, April 15, 2008; 105(15): 5874 - 5878.
[Abstract] [Full Text] [PDF]

Home page
 aacredbookHome page
G. A. Calin and C. M. Croce
MicroRNA-Cancer Connection: The Beginning of a New Tale
Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 667 - 675.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K.-i. Kozaki, I. Imoto, S. Mogi, K. Omura, and J. Inazawa
Exploration of Tumor-Suppressive MicroRNAs Silenced by DNA Hypermethylation in Oral Cancer
Cancer Res., April 1, 2008; 68(7): 2094 - 2105.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Cohen, M. Shmoish, L. Levi, U. Cheruti, B. Levavi-Sivan, and E. Lubzens
Alterations in Micro-Ribonucleic Acid Expression Profiles Reveal a Novel Pathway for Estrogen Regulation
Endocrinology, April 1, 2008; 149(4): 1687 - 1696.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
C. Zhang
MicroRNomics: a newly emerging approach for disease biology
Physiol Genomics, April 1, 2008; 33(2): 139 - 147.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
D. Landi, F. Gemignani, A. Naccarati, B. Pardini, P. Vodicka, L. Vodickova, J. Novotny, A. Forsti, K. Hemminki, F. Canzian, et al.
Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer
Carcinogenesis, March 1, 2008; 29(3): 579 - 584.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. Camps, F. M. Buffa, S. Colella, J. Moore, C. Sotiriou, H. Sheldon, A. L. Harris, J. M. Gleadle, and J. Ragoussis
hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer
Clin. Cancer Res., March 1, 2008; 14(5): 1340 - 1348.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Feber, L. Xi, J. D. Luketich, A. Pennathur, R. J. Landreneau, M. Wu, S. J. Swanson, T. E. Godfrey, and V. R. Litle
MicroRNA expression profiles of esophageal cancer.
J. Thorac. Cardiovasc. Surg., February 1, 2008; 135(2): 255 - 260.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Q. Yin, X. Wang, J. McBride, C. Fewell, and E. Flemington
B-cell Receptor Activation Induces BIC/miR-155 Expression through a Conserved AP-1 Element
J. Biol. Chem., February 1, 2008; 283(5): 2654 - 2662.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
A. J. Schetter, S. Y. Leung, J. J. Sohn, K. A. Zanetti, E. D. Bowman, N. Yanaihara, S. T. Yuen, T. L. Chan, D. L. W. Kwong, G. K. H. Au, et al.
MicroRNA Expression Profiles Associated With Prognosis and Therapeutic Outcome in Colon Adenocarcinoma
JAMA, January 30, 2008; 299(4): 425 - 436.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Yang, W. Kong, L. He, J.-J. Zhao, J. D. O'Donnell, J. Wang, R. M. Wenham, D. Coppola, P. A. Kruk, S. V. Nicosia, et al.
MicroRNA Expression Profiling in Human Ovarian Cancer: miR-214 Induces Cell Survival and Cisplatin Resistance by Targeting PTEN
Cancer Res., January 15, 2008; 68(2): 425 - 433.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. J. Lowery, N. Miller, R. E. McNeill, and M. J. Kerin
MicroRNAs as Prognostic Indicators and Therapeutic Targets: Potential Effect on Breast Cancer Management
Clin. Cancer Res., January 15, 2008; 14(2): 360 - 365.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. Jiang, Y. Gusev, I. Aderca, T. A. Mettler, D. M. Nagorney, D. J. Brackett, L. R. Roberts, and T. D. Schmittgen
Association of MicroRNA Expression in Hepatocellular Carcinomas with Hepatitis Infection, Cirrhosis, and Patient Survival
Clin. Cancer Res., January 15, 2008; 14(2): 419 - 427.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. B. Frankel, N. R. Christoffersen, A. Jacobsen, M. Lindow, A. Krogh, and A. H. Lund
Programmed Cell Death 4 (PDCD4) Is an Important Functional Target of the MicroRNA miR-21 in Breast Cancer Cells
J. Biol. Chem., January 11, 2008; 283(2): 1026 - 1033.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
P. E. Blower, J.-H. Chung, J. S. Verducci, S. Lin, J.-K. Park, Z. Dai, C.-G. Liu, T. D. Schmittgen, W. C. Reinhold, C. M. Croce, et al.
MicroRNAs modulate the chemosensitivity of tumor cells
Mol. Cancer Ther., January 1, 2008; 7(1): 1 - 9.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. F. Sempere, M. Christensen, A. Silahtaroglu, M. Bak, C. V. Heath, G. Schwartz, W. Wells, S. Kauppinen, and C. N. Cole
Altered MicroRNA Expression Confined to Specific Epithelial Cell Subpopulations in Breast Cancer
Cancer Res., December 15, 2007; 67(24): 11612 - 11620.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X.-B. Shi, L. Xue, J. Yang, A.-H. Ma, J. Zhao, M. Xu, C. G. Tepper, C. P. Evans, H.-J. Kung, and R. W. deVere White
An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells
PNAS, December 11, 2007; 104(50): 19983 - 19988.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. L. Skalsky, M. A. Samols, K. B. Plaisance, I. W. Boss, A. Riva, M. C. Lopez, H. V. Baker, and R. Renne
Kaposi's Sarcoma-Associated Herpesvirus Encodes an Ortholog of miR-155
J. Virol., December 1, 2007; 81(23): 12836 - 12845.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Shi, L. Sepp-Lorenzino, M. Prisco, P. Linsley, T. deAngelis, and R. Baserga
Micro RNA 145 Targets the Insulin Receptor Substrate-1 and Inhibits the Growth of Colon Cancer Cells
J. Biol. Chem., November 9, 2007; 282(45): 32582 - 32590.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Lu, D. Katsaros, I. A. Rigault de la Longrais, O. Sochirca, and H. Yu
Hypermethylation of let-7a-3 in Epithelial Ovarian Cancer Is Associated with Low Insulin-like Growth Factor-II Expression and Favorable Prognosis
Cancer Res., November 1, 2007; 67(21): 10117 - 10122.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
H. A. Meijer, M. Bushell, K. Hill, T. W. Gant, A. E. Willis, P. Jones, and C. H. de Moor
A novel method for poly(A) fractionation reveals a large population of mRNAs with a short poly(A) tail in mammalian cells
Nucleic Acids Res., October 11, 2007; (2007) gkm830v1.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Gironella, M. Seux, M.-J. Xie, C. Cano, R. Tomasini, J. Gommeaux, S. Garcia, J. Nowak, M. L. Yeung, K.-T. Jeang, et al.
Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development
PNAS, October 9, 2007; 104(41): 16170 - 16175.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
X. Tang, J. Gal, X. Zhuang, W. Wang, H. Zhu, and G. Tang
A simple array platform for microRNA analysis and its application in mouse tissues
RNA, October 1, 2007; 13(10): 1803 - 1822.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. V. Iorio, R. Visone, G. Di Leva, V. Donati, F. Petrocca, P. Casalini, C. Taccioli, S. Volinia, C.-G. Liu, H. Alder, et al.
MicroRNA Signatures in Human Ovarian Cancer
Cancer Res., September 15, 2007; 67(18): 8699 - 8707.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Berkhout and K.-T. Jeang
RISCy Business: MicroRNAs, Pathogenesis, and Viruses
J. Biol. Chem., September 14, 2007; 282(37): 26641 - 26645.
[Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
M. Kruhoffer, L. Dyrskjot, T. Voss, R. L.P. Lindberg, R. Wyrich, T. Thykjaer, and T. F. Orntoft
Isolation of Microarray-Grade Total RNA, MicroRNA, and DNA from a Single PAXgene Blood RNA Tube
J. Mol. Diagn., September 1, 2007; 9(4): 452 - 458.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
W. Zhang, J. E. Dahlberg, and W. Tam
MicroRNAs in Tumorigenesis: A Primer
Am. J. Pathol., September 1, 2007; 171(3): 728 - 738.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. D. Johnson, A. Esquela-Kerscher, G. Stefani, M. Byrom, K. Kelnar, D. Ovcharenko, M. Wilson, X. Wang, J. Shelton, J. Shingara, et al.
The let-7 MicroRNA Represses Cell Proliferation Pathways in Human Cells
Cancer Res., August 15, 2007; 67(16): 7713 - 7722.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Loffler, K. Brocke-Heidrich, G. Pfeifer, C. Stocsits, J. Hackermuller, A. K. Kretzschmar, R. Burger, M. Gramatzki, C. Blumert, K. Bauer, et al.
Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer
Blood, August 15, 2007; 110(4): 1330 - 1333.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Galardi, N. Mercatelli, E. Giorda, S. Massalini, G. V. Frajese, S. A. Ciafre, and M. G. Farace
miR-221 and miR-222 Expression Affects the Proliferation Potential of Human Prostate Carcinoma Cell Lines by Targeting p27Kip1
J. Biol. Chem., August 10, 2007; 282(32): 23716 - 23724.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
A. Goga and C. Benz
Anti-Oncomir Suppression of Tumor Phenotypes
Mol. Interv., August 1, 2007; 7(4): 199 - 202.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
T. Thum, P. Galuppo, C. Wolf, J. Fiedler, S. Kneitz, L. W. van Laake, P. A. Doevendans, C. L. Mummery, J. Borlak, A. Haverich, et al.
MicroRNAs in the Human Heart: A Clue to Fetal Gene Reprogramming in Heart Failure
Circulation, July 17, 2007; 116(3): 258 - 267.
<