Equine Glandular Gastric Disease: Prevalence and Potential Mechanisms of Formation
Abstract
The pathophysiology of and risk factors for equine glandular gastric disease (EGGD) formation are poorly understood. The present studies aimed to explore risk factors for spontaneous EGGD, and evaluate the role of prostaglandin synthesis in NSAID-induced gastric glandular disease formation. In a population of 86 show jumping Warmblood horses, prevalence of EGGD grade ≥2 was 49%. Competing at the national level was the risk factor identified in the multivariable analysis for grade ≥2 EGGD. In order to evaluate the role of prostaglandin concentration in NSAID-induced EGGD, twelve horses were treated with either phenylbutazone or placebo for one week. Glandular disease score increased in the phenylbutazone group. Prostaglandin concentrations in glandular gastric biopsies increased over time in both treatment groups. In summary, competition level appears to be a risk factor for spontaneous EGGD. Decreased prostaglandin concentration does not appear to be a primary contributor to NSAID-induced EGGD.
Description
Keywords
Veterinary Science
Citation
Pedersen, S. K. (2017). Equine Glandular Gastric Disease: Prevalence and Potential Mechanisms of Formation (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25932