Metal-Based Drugs 
Volume 7 (2000), Issue 5, Pages 233-236
doi:10.1155/MBD.2000.233

Synthesis, Characterization and Antitumour Activity of Some Butyltin(IV) Cysteaminates and N,N-Dimethylcysteaminates

Marcel Gielen,1 Karel Handlir,2 Martin Hollein,2 and Dick de Vos3

 1Departement of General and Organic Chemistry AOSC, Faculty of Applied Sciences, Free University of Brussels VUV, Pleinlaan 2, Brussels B-1050, Belgium
2Departement of General and Inorganic Chemistry, Faculty of Chemical Technology, University of Pardubice, Nam. Cs. legii 565, Pardubice 53210, Czech Republic
3Pharmachemie B. V., Haarlem, The Netherlands
Received 22 September 2000; Accepted 19 October 2000

Abstract

The synthesis and characterization of four di- and tri-n-butyltin cysteaminates and N,N-dimethylcysteaminates and three protonated / quaternized derivatives are reported. They all exhibit moderate or high in vitro cytotoxic activity. Six of seven compounds presented in this work are more active than cisplatin, etoposide and 5-fluorouracil, but less active than methotrexate and doxorubicin.