Metal-Based Drugs 
Volume 7 (2000), Issue 4, Pages 177-183
doi:10.1155/MBD.2000.177

Symmetric 1,1'-Dimethylferrocene-Derived Amino Acids: Their Synthesis, Characterization, Ligational and Biological Properties With Cu(II), Co(II) and Ni(II) Ions

Zahid H. Chohan

 Department of Chemistry, Islamia University, Bahawalpur, Pakistan
Received 28 July 2000; Accepted 11 September 2000

Abstract

Some novel symmetric 1,1′-dimethylferrocene derived amino acids have been prepared by the reaction of 1,1′-ferrocenedimethyldichloride with amino acids (glycine, alanine, phenylalanine and tyrosine). Their Cu(II), Co(II) and Ni(II) complexes, of the type [M(L)] where [M = Cu(II) and L = L1-L5] and [M(L)Cl2] where [M-Co(II)and Ni(II), L = L1-L5] have been prepared. The dicarboxylic acids and their metal complexes were characterized by their physical, analytical and spectral data. The [M(L)] complexes showed a square planar geometry whereas an octahedral geometry was observed for [M(L)Cl2] complexes. The title dicarboxylic acids and their metal complexes have also been screened for their antibacterial activity.