Metal-Based Drugs 
Volume 5 (1998), Issue 6, Pages 347-354
doi:10.1155/MBD.1998.347

Synthesis, Ligational and Biological Properties of Cobalt(II), Copper(II), Nickel(II) and Zinc(II) Complexes With Pyrazinedicarboxaimide Derived Furanyl, Thienyl and Pyrrolyl Compounds

Zahid H. Chohan,1 S. K. A. Sherazi,1 M. Praveen,2 and M. S. Iqbal3

 1Department of Chemistry, Islamia University, Bahavalpur, Pakistan
2Department of Chemistry, Washington University, St. Louis 63130, USA
3Himont Pharmaceutical and Chemical Laboratories, Lahore, Pakistan
Received 21 October 1998; Accepted 11 November 1998

Abstract

Preparation, ligational and biological properties of some pyrazinedicarboxaimide derived furanyl, thienyl and pyrrolyl compounds with Co(ll), Cu(ll), Ni(ll) and Zn(ll) metals are described. Magnetic moments, electronic, infrared, nuclear magnetic resonance spectra and elemental analysis data indicate that co-ordination of the ligands with the metal ions take place through the pyrazine ring nitrogen, azomethine nitrogen and heteroatom of heterocyclic ring system. The compounds are all novel and are proposed to possess an octahedral geometry for Co(ll) and Ni(ll), and a distorted octahedral geometry for Cu(ll) and Zn(ll) complexes. The comparative biological properties of the title ligands and their metal chelates against different bacterial species are also described.