Metal-Based Drugs 
Volume 5 (1998), Issue 3, Pages 161-170
doi:10.1155/MBD.1998.161

Pd(II) and Pt(II) Complexes of Schiff Thiobases Derived From 2-Carbonylpyridine

M. Gómez-Bosquet,1 V. Moreno,1 M. Font-Bardía,2 and X. Solans2

 1Departament de Química Inorgànica, Universitat de Barcelona, Avgda Diagonal, 647, Barcelona 08028, Spain
2Departament de Cristallografia Dipòsits Minerals, Martí i Franquès s/n, Barcelona 08028, Spain
Received 26 March 1998; Accepted 20 April 1998

Abstract

Pd(ll) and Pt(ll) complexes of three series of Schiff thiobases derived from 2- carbonylpyridine have been synthesized and characterized. The crystal structure of the Pt(ll) derivative of methyl-3-(2-pyridylmethylene)hydrazinecarbodithioate (HFp) was resolved. The ligand coordinates the platinum ion in tridentate fashion by heterocycle and imine nitrogen and thiocarbonyl sulfur. The fourth ligand is a chloride ion. The structure of the complexes is suitable for the formation of monofunctional adducts with DNA. Studies on the interaction of the complexes with Calf thymus DNA by CD reveal modifications in the B form of lineal DNA. Interaction with plasmid DNA was also confirmed in the images obtained by atomic force microscopy.