Metal-Based Drugs 
Volume 4 (1997), Issue 4, Pages 193-197
doi:10.1155/MBD.1997.193

Di-n-Butyl-, Tri-n-Butyl- and Triphenyltin dl-Terebates: Synthesis, Characterization and In Vitro Antitumour Activity

Marcel Gielen,1 Huairang Ma,1,3 Abdeslam Bouhdid,1 Hassan Dalil,1 Monique Biesemans,1,2 and Rudolph Willem1,2

 1Department of General and Organic Chemistry, Faculty of Applied Sciences, Free University of Brussels V.U.B., Pleinlaan 2, Brussels B-1050, Belgium
2High Resolution NMR Centre, Free University of Brussels V.U.B., Pleinlaan 2, Brussels B-1050, Belgium
3Department of Chemistry, Northwest University, ShaanXi, Xian 710 069, China
Received 25 April 1997; Accepted 6 May 1997

Abstract

Di-n-butyltin, tri-n-butyltin and triphenyltin terebates were screened against several human tumour cell lines and found comparably or more active than carboplatin, cis-platin, 5-fluorouracil, methotrexate and doxorubicin, some reference compounds used clinically.