Metal-Based Drugs 
Volume 3 (1996), Issue 2, Pages 75-78
doi:10.1155/MBD.1996.75

Triphenyltin Ortho-Aminophenyl- and 2-Pyridyl-Thiolates: Synthesis and In Vitro Antitumour Activity

Marcel Gielen,1 Abdeslam Bouhdid,1 Edward R. T. Tiekink,2 Dick de Vos,3 and Rudolph Willem1,2

 1Free University of Brussels V.U.B., Pleinlaan 2, Department of General and Organic Chemistry, Faculty of Applied Sciences, Brussels B-1050, Belgium
2Free University of Brussels V.U.B., Pleinlaan 2, High Resolution NMR Centre, Brussels B-1050, Belgium
3Department of Chemistry, The University of Adelaide, Adelaide 5005, S. A., Australia
4Medical Department, Pharmachemie BV, Haarlem NL-2003 RN, Netherlands Antilles
Received 18 January 1996; Accepted 27 February 1996

Abstract

The synthesis, spectroscopic characterization and in vitro antitumour activity of two triorganotin compounds, triphenyltin ortho-aminophenylthiolate (1) and triphenyltin 2-pyridylthiolate, compound (2) are reported. The structure of 1 is confirmed by X-ray diffraction, with the tin atom in a distorted tetrahedral geometry because of monodentate coordination, as a thiolate (Sn-S 2.431(2) Å), of the ortho-aminophenylthiolate ligand. The in vitro antitumour activities of 1 and 2, against a number of cell lines, are comparable to those exhibited by methotrexate and doxorubicin, and higher than those of carboplatin and cisplatin.