International Journal of Biomedical Imaging 
Volume 2006 (2006), Article ID 53050, 11 pages
doi:10.1155/IJBI/2006/53050

Elasto-mammography: Theory, Algorithm, and Phantom Study

Z. G. Wang,1 Y. Liu,2 L. Z. Sun,3 G. Wang,2 and L. L. Fajardo2

 1Department of Civil and Environmental Engineering, The University of Iowa, Iowa City 52242, IA, USA
2Department of Radiology, The University of Iowa, Iowa City 52242, IA, USA
3Department of Civil and Environmental Engineering, University of California, Irvine 92697, CA, USA
Received 4 September 2005; Accepted 7 November 2005

Recommended by Jie Tian

Abstract

A new imaging modality framework, called elasto-mammography, is proposed to generate the elastograms of breast tissues based on conventional X-ray mammography. The displacement information is extracted from mammography projections before and after breast compression. Incorporating the displacement measurement, an elastography reconstruction algorithm is specifically developed to estimate the elastic moduli of heterogeneous breast tissues. Case studies with numerical breast phantoms are conducted to demonstrate the capability of the proposed elasto-mammography. Effects of noise with measurement, geometric mismatch, and elastic contrast ratio are evaluated in the numerical simulations. It is shown that the proposed methodology is stable and robust for characterization of the elastic moduli of breast tissues from the projective displacement measurement.