Mediators of Inflammation 
Volume 2008 (2008), Article ID 781425, 11 pages
doi:10.1155/2008/781425
Research Article

Effects of Radix Adenophorae and Cyclosporine A on an OVA-Induced Murine Model of Asthma by Suppressing to T Cells Activity, Eosinophilia, and Bronchial Hyperresponsiveness

Seong-Soo Roh,1 Seung-Hyung Kim,2 Young-Cheol Lee,3 and Young-Bae Seo4

 1Laboratory of Herbology, College of Oriental Medicine, Daegu Hanny University, Daegu 706060, South Korea
2Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon 300716, South Korea
3Laboratory of Herbology, College of Oriental Medicine, Sangji University, Wonju 220702, South Korea
4Laboratory of Herbology, College of Oriental Medicine, Daejeon University, Daejeon 300716, South Korea
Received 22 October 2007; Accepted 2 January 2008

Recommended by Freek Zijlstra

Abstract

The present study is performed to investigate the inhibitory effects of Radix Adenophorae extract (RAE) on ovalbumin-induced asthma murine model. To study the anti-inflammatory and antiasthmatic effects of RAE, we examined the development of pulmonary eosinophilic inflammation and inhibitory effects of T cells in murine by RAE and cyclosporine A (CsA). We examined determination of airway hyperresponsiveness, flow cytometric analysis (FACS), enzyme-linked immunosorbent assay (ELISA), quantitative real time (PCR), hematoxylin-eosin staining, and Masson trichrome staining in lung tissue, lung weight, total cells, and eosinophil numbers in lung tissue. We demonstrated how RAE suppressed development on inflammation and decreased airway damage.