EURASIP Journal on Wireless Communications and Networking 
Volume 2008 (2008), Article ID 495185, 10 pages
doi:10.1155/2008/495185
Research Article

Continuous Drug Infusion for Diabetes Therapy: A Closed-Loop Control System Design

Jiming Chen,1 Kejie Cao,1 Youxian Sun,1 Yang Xiao,2 and Xu (Kevin) Su3

 1State Key Laboratory of Industrial Control Technology, Institute of Industrial Process Control, Zhejiang University, Hangzhou 310027, China
2Department of Computer Science, The University of Alabama, Tuscaloosa, AL 35487, USA
3Department of Computer Science, University of Texas at San Antonio, San Antonio, TX 78249, USA
Received 15 July 2007; Revised 25 November 2007; Accepted 5 December 2007

Recommended by Hui Chen

Abstract

While a typical way for diabetes therapy is discrete insulin infusion based on long-time interval measurement, in this paper, we design a closed-loop control system for continuous drug infusion to improve the traditional discrete methods and make diabetes therapy automatic in practice. By exploring the accumulative function of drug to insulin, a continuous injection model is proposed. Based on this model, proportional-integral-derivative (PID) and fuzzy logic controllers are designed to tackle a control problem of the resulting highly nonlinear plant. Even with serious disturbance of glucose, such as nutrition absorption at meal time, the proposed scheme can perform well in simulation experiments.