HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (13) Citing Articles via Google Scholar Google Scholar Articles by Khosravani, H. Articles by Zamponi, G. W. Search for Related Content PubMed PubMed Citation Articles by Khosravani, H. Articles by Zamponi, G. W.

Voltage-Gated Calcium Channels and Idiopathic Generalized Epilepsies

Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada

The idiopathic generalized epilepsies encompass a class of epileptic seizure types that exhibit a polygenic and heritable etiology. Advances in molecular biology and genetics have implicated defects in certain types of voltage-gated calcium channels and their ancillary subunits as important players in this form of epilepsy. Both T-type and P/Q-type channels appear to mediate important contributions to seizure genesis, modulation of network activity, and genetic seizure susceptibility. Here, we provide a comprehensive overview of the roles of these channels and associated subunits in normal and pathological brain activity within the context of idiopathic generalized epilepsy.

This article has been cited by other articles:

				B. Beyer, C. Deleuze, V. A. Letts, C. L. Mahaffey, R. M. Boumil, T. A. Lew, J. R. Huguenard, and W. N. Frankel Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4 Hum. Mol. Genet., June 15, 2008; 17(12): 1738 - 1749. [Abstract] [Full Text] [PDF]

				Y.-H. Hsu, W.-T. Lee, and C. Chang Multiparametric MRI evaluation of kainic acid-induced neuronal activation in rat hippocampus Brain, December 1, 2007; 130(12): 3124 - 3134. [Abstract] [Full Text] [PDF]

				M. Weiergraber, M. Henry, K. Radhakrishnan, J. Hescheler, and T. Schneider Hippocampal Seizure Resistance and Reduced Neuronal Excitotoxicity in Mice Lacking the Cav2.3 E/R-Type Voltage-Gated Calcium Channel J Neurophysiol, May 1, 2007; 97(5): 3660 - 3669. [Abstract] [Full Text] [PDF]