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Physiology 21: 38-47, 2006; doi:10.1152/physiol.00042.2005
1548-9213/06 $8.00
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Physiology, Vol. 21, No. 1, 38-47, February 2006
© 2006 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Development and Regulation of Dendritic Spine Synapses

Barbara Calabrese, Margaret S. Wilson and Shelley Halpain

Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, California

shelley{at}scripps.edu

Dendritic spines are small protrusions from neuronal dendrites that form the postsynaptic component of most excitatory synapses in the brain. They play critical roles in synaptic transmission and plasticity. Recent advances in imaging and molecular technologies reveal that spines are complex, dynamic structures that contain a dense array of cytoskeletal, transmembrane, and scaffolding molecules. Several neurological and psychiatric disorders exhibit dendritic spine abnormalities.






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