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THEMES

Gastrointestinal Stem Cells I. Pancreatic stem cells

¹Institute of Bioengineering, University Miguel Hernandez, Alicante; ²Department of Environmental Sciences and Laboratario Andalur de Terapia Celular y Diabetes, University Pablo Olavide and Junta de Andalucía, Seville; and ³Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, Spain

The transplantation of islets isolated from donor pancreas has renewed the interest in cell therapy for the treatment of diabetes. In addition, the capacity that stem cells have to differentiate into a wide variety of cell types makes their use ideal to generate -cells for transplantation therapies. Several studies have reported the generation of insulin-secreting cells from embryonic and adult stem cells that normalized blood glucose values when transplanted into diabetic animal models. Finally, although much work remains to be done, there is sufficient evidence to warrant continued efforts on stem cell research to cure diabetes.

diabetes; embryonic stem cells; adult stem cells; differentiation