HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) All Versions of this Article: jnnp.2006.096800v1 78/3/240    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Johnson, K A Articles by Albert, M S Search for Related Content PubMed PubMed Citation Articles by Johnson, K A Articles by Albert, M S Topic Collections Related Article

Single photon emission computed tomography perfusion differences in mild cognitive impairment

¹ Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
² Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
³ Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
⁴ Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Correspondence to:
Correspondence to:
Dr K A Johnson
Departments of Radiology (Nuclear Medicine) and Neurology, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA; kajohnson{at}partners.org

Objective: To relate cerebral perfusion abnormalities to subsequent changes in clinical status among patients with mild cognitive impairment (MCI).

Methods: Perfusion single photon emission computed tomography (SPECT) images were acquired in 105 elderly patients without dementia with MCI, using 99mTc-HMPAO. Clinical outcome after a 5-year follow-up period was heterogeneous.

Results: Baseline SPECT data differed in those patients with MCI who were later diagnosed with Alzheimer’s disease (the converter group) from those patients with MCI who experienced clinically evident decline but did not progress to a diagnosis of Alzheimer’s disease within the follow-up period (the decliner group), from patients with MCI who had no clinical evidence of progression (the stable group), and from a group of 19 normal subjects (the control group). The most consistent decreases in relative perfusion in converters compared with the normal, stable and decliner groups were observed in the caudal anterior cingulate, and in the posterior cingulate. In addition, converters showed increased relative perfusion in the rostral anterior cingulate in comparison to the stable and decliner groups. A group of patients with Alzheimer’s disease were also included for purposes of comparison. The group of patients with Alzheimer’s disease at baseline differed from each of the other groups, with temporoparietal regions showing the most significant reductions in perfusion.

Conclusions: These results suggest that clinical heterogeneity in MCI is reflected in SPECT perfusion differences, and that the pattern of perfusion abnormalities evolves with increasing clinical severity.

Abbreviations: ANOVA, analysis of variance; CDR, clinical dementia rating; CDR-SB, CDR Sum of Boxes; MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination; MRI, magnetic resonance imaging; MTL, medial temporal lobe; PET, positron emission tomography; ROI, regions of interest; SPECT, single photon emission computed tomography; SPM, statistical parametric mapping; TMT, Trailmaking Test

Related Article

Biot’s breathing

Eelco F M Wijdicks
J. Neurol. Neurosurg. Psychiatry 2007 78: 512-513. [Extract] [Full Text] [PDF]