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Peripapillary fundus perimetry in eyes with glaucoma

¹ Department of Ophthalmology, University of Padova, Padova, Italy
² Fondazione GB Bietti per l’Oftalmologia, IRCCS, Roma, Italy

Correspondence to:
Correspondence to:
E Convento
Department of Ophthalmology, University of Padova, Via Giustiniani, 2, Padova 35128, Italy; enrica_convento{at}yahoo.it

Aims: To evaluate, with fundus perimetry, the peripapillary differential light threshold (DLT) in eyes with glaucoma and ocular hypertension (OHT), and compare it with peripapillary retinal nerve fibre layer (RNFL) thickness.

Methods: 35 glaucomatous, 29 OHT and 24 control eyes were included. Peripapillary DLT at 1° from the optic nerve head was quantified with fundus perimetry; peripapillary RNFL thickness was measured over the same area by optical coherence tomography.

Results: Mean (SD) peripapillary DLT was 19.2 (1.7), 17.6 (4.2) and 10.1 (6.9) dB in control, OHT and glaucomatous eyes, respectively (p<0.001). Mean (SD) RNFL thickness was 98.4 (35.3), 83.9 (35.1) and 55.8 (28.2) µm, respectively (p<0.001). Mean peripapillary DLT showed higher sensitivity and specificity in differentiating the three groups compared with RNFL thickness.

Conclusion: Progressive, significant reduction of peripapillary DLT was documented in OHT and glaucomatous eyes compared with controls (p<0.001). DLT reduction parallels RNFL reduction.

Abbreviations: AROC, area under the receiver operating characteristic curve; DLT, differential light threshold; IOP, intraocular pressure; OCT, optical coherence tomography; OHT, ocular hypertension; ONH, optic nerve head; RNFL, retinal nerve fibre layer; ROC curve, receiver operating characteristic curve

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