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Unusual presentation of more common disease/injury
Isochromosome 9q as a sole anomaly in an Omani boy with acute lymphoblastic leukaemia
  1. Udayakumar Muthappa Achandira1,
  2. Anil V Pathare2,
  3. Salam Al Kindi1,
  4. David Dennison2,
  5. Said Al Yahyaee2
  1. 1
    Sultan Qaboos University, College of Medicine and Health Sciences, PO Box 35, Muscat, 123, Oman
  2. 2
    Sultan Qaboos University Hospital, Department of Haematology, Muscat, PO Box 38, PC 123, Oman
  1. Udayakumar Muthappa Achandira, amuk19{at}hotmail.com

Summary

This report describes a case of acute lymphoblastic leukaemia in which isochromosome 9q (i(9q)) was the sole acquired cytogenetic abnormality. The Immunophenotype showed positivity for CD3, CD4, CD5, CD7, CD8, CD10, CD71, CD117 and TdT, consistent with T cell acute lymphoblastic leukaemia (ALL). The chromosomal analysis of bone marrow showed 46,XY,i(9)(q10) in all the metaphases analysed. The bone marrow morphology was ALL-L2 as per the French–American–British criteria. Isochromosomes are rare chromosomal abnormalities in childhood ALL and the effect of i(9q) is not well established. The patient’s good response to therapy with normal cytogenetics within a month of induction, and disease-free survival after bone marrow transplant are indicative of a good prognosis in such cases.

https://doi.org/10.1136/bcr.09.2008.0890

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    Footnotes

    • Competing interests: none.

    • Patient consent: Patient/guardian consent was obtained for publication.