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Relationships between Effects of Ag Nanoparticles and Ag Salt on Behavioral and Cognitive Functions of Mice and Ageing

  • NANOBIOMEDICINE AND NANOPHARMACEUTICS
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Abstract

Silver in different forms is used for medical purposes from Ancient times. It is not yet well known, which form of silver is more biocompatible and less toxic. Here we considered silver nanoparticles and silver citrate. Also, the relationships of neurotoxicity of silver compounds with ageing factor is not yet described. To assess the role of nanoform in neurotoxicity of silver and role of ageing a long-term experiment was conducted. We had four control groups of intact mice and four experimental groups which were exposed to silver nanoparticles and silver citrate for two months. Four groups of mice were introduced into the experiment since the age of five months to assess ageing factors. It was shown that the nanoform does play a certain role in neurotoxicity of silver. Silver citrate seems to be a more preferable silver compound. Ageing can be regarded as a positive factor that neutralizes toxic action of silver compounds. It may be due to the development of physiological/cognitive functions with the age as well as adaptation to unnatural content in the individual cages that is definitely stressful for mice.

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ACKNOWLEDGMENTS

The authors are grateful to the leading researcher of the Federal State Budgetary Scientific Institution “Federal Research Center of Nutrition and Biotechnology” I. V. Gmo-shynskiy for advices on research preparation.

Funding

The study was partially financed by the Russian Foundation for Basic Research (grant no. 21-315-70016) and partially supported by the Ministry of Science and Higher Education of the Russian Federation, the contract 075-15-2021-709, unique identifier of the project RF-2296.61321X0037 (equipment maintenance).

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Authors and Affiliations

  1. National Research Center “Kurchatov Institute”, 123182, Moscow, Russia

    A. A. Antsiferova, M. Yu. Kopaeva & P. K. Kashkarov

  2. Moscow Institute of Physics and Technologies, Moscow oblast, 141700, Dolgoprudny, Russia

    A. A. Antsiferova & P. K. Kashkarov

  3. Department of Physics, Lomonosov Moscow State University, 119991, Moscow, Russia

    P. K. Kashkarov

Authors
  1. A. A. Antsiferova
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  2. M. Yu. Kopaeva
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  3. P. K. Kashkarov
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Corresponding author

Correspondence to A. A. Antsiferova.

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Institutional Review Board Statement: The study was conducted according to the rules of the Ministry of Health of the Russian Federation (no. 267 of 19.06.2013), and approved by the Local Ethics Committee for Biomedical Research of the National Research Center “Kurchatov Institute” (no. 01 from February 10, 2017 and no. 01 from October 6, 2021).

Conflict of interest. The authors declare no conflicts of interest.

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Antsiferova, A.A., Kopaeva, M.Y. & Kashkarov, P.K. Relationships between Effects of Ag Nanoparticles and Ag Salt on Behavioral and Cognitive Functions of Mice and Ageing. Nanotechnol Russia 17, 857–865 (2022). https://doi.org/10.1134/S2635167622340018

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  • DOI: https://doi.org/10.1134/S2635167622340018

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