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Morphofunctional fundamentals for peptide regulation of aging

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Abstract

Processes of aging related to different morphological and functional changes due to pathological or compensatory reactions are considered. Long-term studies of the use of peptide bioregulators showed their efficiency in the prophylaxis and treatment of pathologies characteristic for aged persons. The basis of the geroprotective action of peptides is revealed to be their capacity for active protein synthesis at the molecular level, cytodifferentiation activation, and proliferation on the cell level. At the same time, they prevent the development of mitochondrial apoptosis and at tissue level restore morphofunctional interactions that are weakened in aging.

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Authors and Affiliations

  1. Institute of Bioregulation and Gerontology, Russian Academy of Medical Sciences, St. Petersburg, Russia

    V. Kh. Khavinson, N. S. Lin’kova, A. V. Trofimov, V. O. Polyakova, N. N. Sevost’yanova & I. M. Kvetnoy

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  1. V. Kh. Khavinson
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  2. N. S. Lin’kova
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  3. A. V. Trofimov
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  4. V. O. Polyakova
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  5. N. N. Sevost’yanova
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  6. I. M. Kvetnoy
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Correspondence to V. Kh. Khavinson.

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Original Russian Text © V.Kh. Khavinson, N.S. Lin’kova, A.V. Trofimov, V.O. Polyakova, N.N. Sevost’yanova, I.M. Kvetnoy, 2011, published in Uspekhi Sovremennoi Biologii, 2011, Vol. 131, No. 2, pp. 115–121.

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Khavinson, V.K., Lin’kova, N.S., Trofimov, A.V. et al. Morphofunctional fundamentals for peptide regulation of aging. Biol Bull Rev 1, 390–394 (2011). https://doi.org/10.1134/S2079086411040025

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  • DOI: https://doi.org/10.1134/S2079086411040025

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