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AEDG Peptide Regulation of the Expression of Human Circadian Rhythm Genes upon Accelerated Aging of the Pineal Gland

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Abstract

Night work desynchronizes biorhythms, disturbs melatonin production, and accelerates pineal-gland aging. A promising geroprotector for the restoration of pineal melatonin synthesis is AEDG (Ala-Glu-Asp-Gly) peptide. AEDG peptide increases 6-sulfatoxymelatonin (6-SOMT) excretion in the urine of middle-aged people by 1.7 times. Moreover, AEDG peptide normalizes the hyperexpression of the Clock and Csnk1e circadian genes in leukocytes and increases Cry2 gene hypoexpression in peripheral blood lymphocytes by two times in people with reduced epiphyseal melatonin-production. The geroprotective effect of AEDG peptide is based on its ability to restore epiphyseal melatonin production via regulation of the expression of human circadian genes.

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Authors and Affiliations

  1. Institute of Predictive Medicine, Galaxia Sea View, 3022, Limassol, Cyprus

    O. M. Ivko

  2. St. Petersburg Institute of Bioregulation and Gerontology, 197110, St. Petersburg, Russia

    O. M. Ivko, N. S. Linkova, A. R. Ilina & G. A. Ruzhak

  3. Academy of Postgraduate Education, 125371, Moscow, Russia

    N. S. Linkova & A. A. Sharova

Authors
  1. O. M. Ivko
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  2. N. S. Linkova
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  3. A. R. Ilina
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  4. A. A. Sharova
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  5. G. A. Ruzhak
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Correspondence to O. M. Ivko.

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Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by E. Makeeva

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Ivko, O.M., Linkova, N.S., Ilina, A.R. et al. AEDG Peptide Regulation of the Expression of Human Circadian Rhythm Genes upon Accelerated Aging of the Pineal Gland. Adv Gerontol 11, 53–58 (2021). https://doi.org/10.1134/S2079057021010380

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  • DOI: https://doi.org/10.1134/S2079057021010380

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