Abstract
This study focuses on the development of the polymeric composition of linezolid based on biodegradable polymeric carriers. Polymeric compositions within linezolid were prepared by the simple emulsification method using a series of polymers such as PLGA 50/50, PLGA 75/25, PLGA-COOH 50/50, Eudragit RL, and Eudragit RS. The best characteristics were achieved by a composition obtained by using the polymer PLGA 50/50. The content of linezolid in the composition was 9.4 ± 0.47%, the inclusion efficiency was 50 ± 2.50%, and the particle size was 275 ± 13 nm. A study of antimicrobial activity of the polymer composition was performed by standard methods using cambric tests on Myulton-Hiller medium at a concentration of active ingredient 500 μg/mL. Experimental results demonstrated that the polymeric composition exhibited higher specific activity against Staphylococcus aureus than the substance.
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Original Russian Text © A.A. Novikova, V.V. Zavarzina, E.A. Vorontcov, S.E. Severin, E.S. Severin, 2014, published in Rossiiskie Nanotekhnologii, 2014, Vol. 9, Nos. 7–8.
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Novikova, A.A., Zavarzina, V.V., Vorontcov, E.A. et al. Preparation of polymeric composition of linezolid and study of its antimicrobial activity in vitro. Nanotechnol Russia 9, 453–456 (2014). https://doi.org/10.1134/S1995078014040132
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DOI: https://doi.org/10.1134/S1995078014040132