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In HIV-Infected Immunological Non-Responders, Hepatitis C Virus Eradication Contributes to Incomplete Normalization of Systemic Inflammation Indexes, but Does Not Lead to Rapid CD4+ T-Cell Count Recovery

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

In HIV-positive individuals taking antiretroviral therapy, coinfection with hepatitis C virus (HCV) increases systemic inflammation, which interferes with the CD4+ T-cells regeneration. This study evaluated the effect of HCV eradication on systemic inflammation and CD4+ T-cell regeneration in patients who gave poor response to antiretroviral therapy, the so-called “immunological non-responders” (INRs). HIV-infected patients who received a course of direct-acting antivirals for treating hepatitis C were examined. The control groups included HIV/HCV-coinfected INRs and relatively healthy volunteers. It was established for the first time that HCV eradication is not accompanied by a complete suppression of systemic inflammation, but improves the T-cell pool composition: in INRs, the blood CD4+/CD8+ T-lymphocyte ratio increases and approaches those of healthy individuals. Apparently, in INRs treated for hepatitis C, the immune system recovery takes time and may be incomplete.

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ACKNOWLEDGMENTS

In this study, we used the equipment of the Core Facility “Investigations of Materials and Substances,” Perm Federal Research Center, Ural Branch, Russian Academy of Sciences.

Funding

The study was carried out under the state assignment (no. 121112500044-9) and was supported by the Russian Foundation for Basic Research and the Perm krai within the framework of the scientific project no. 20-415-596002.

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Authors and Affiliations

  1. Perm Federal Research Center, Ural Branch, Russian Academy of Sciences, Perm, Russia

    E. V. Saidakova, L. B. Korolevskaya, N. G. Shmagel, V. V. Vlasova, K. Yu. Shardina,  V. A. Chereshnev & K. V. Shmagel

  2. Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, Yekaterinburg, Russia

    V. A. Chereshnev

Authors
  1. E. V. Saidakova
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  2. L. B. Korolevskaya
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  3. N. G. Shmagel
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  4. V. V. Vlasova
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  5. K. Yu. Shardina
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  6. V. A. Chereshnev
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  7. K. V. Shmagel
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Corresponding author

Correspondence to E. V. Saidakova.

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Conflict of interest. The authors declare that they have no conflicts of interest.

Statement of compliance with standards of research involving humans as subjects. The work plan was approved by the Ethics Committee of the Perm Regional Center for Combating AIDS and Infectious Diseases (committee registration no. IRB00008964), protocol No. 31 dated March 3, 2017. Informed consent was obtained from each participant.

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Translated by M. Batrukova

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Saidakova, E.V., Korolevskaya, L.B., Shmagel, N.G. et al. In HIV-Infected Immunological Non-Responders, Hepatitis C Virus Eradication Contributes to Incomplete Normalization of Systemic Inflammation Indexes, but Does Not Lead to Rapid CD4+ T-Cell Count Recovery. Dokl Biochem Biophys 512, 274–278 (2023). https://doi.org/10.1134/S1607672923700448

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  • DOI: https://doi.org/10.1134/S1607672923700448

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