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Transcription factor Oct-1 stimulates the release of Mts1/S100A4 protein by the cancer cells

  • Biochemistry, Biophysics and Molecular Biology
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Abstract

The effect of the transcription factor Oct-1 (POU2F1) on the expression of the tumor cell marker metastasin (Mts1/S100A4) was studied. Comparative analysis of various tumor lines showed no clear correlation between the expression level of Mts1/S100A4 and the content of Oct-1. However, at stable transfection of tumor cells with Oct-1A, Oct-1L, and Oct-1X isoforms we detected an elevated level of Oct-1, which stimulated Mts1/S100A4 secretion. These findings extend our understanding of the molecular mechanisms of the tumorigenic effect of Oct-1.

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Authors and Affiliations

  1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia

    T. N. Portseva, A. V. Brechalov, E. A. Dukhanina, A. G. Stepchenko, E. V. Pankratova & S. G. Georgieva

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  1. T. N. Portseva
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  2. A. V. Brechalov
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  3. E. A. Dukhanina
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  4. A. G. Stepchenko
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  5. E. V. Pankratova
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  6. S. G. Georgieva
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Corresponding author

Correspondence to T. N. Portseva.

Additional information

Original Russian Text © T.N. Portseva, A.V. Brechalov, E.A. Dukhanina, A.G. Stepchenko, E.V. Pankratova, S.G. Georgieva, 2016, published in Doklady Akademii Nauk, 2016, Vol. 467, No. 4, pp. 481–483.

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Portseva, T.N., Brechalov, A.V., Dukhanina, E.A. et al. Transcription factor Oct-1 stimulates the release of Mts1/S100A4 protein by the cancer cells. Dokl Biochem Biophys 467, 121–123 (2016). https://doi.org/10.1134/S1607672916020125

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  • DOI: https://doi.org/10.1134/S1607672916020125

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