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A comprehensive study of interactions between lectins and glycoproteins for the development of effective theranostic nanoagents

  • Biochemistry, Biophysics and Molecular Biology
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Abstract

A comprehensive study of the interactions between lectins and glycoproteins possessing different glycosylation profiles in the composition of nanoparticles was carried out in order to find specifically interacting protein pairs for the creation of novel classes of multifunctional nanoagets that based on protein-assisted selfassembly. We obtained information about specific interactions of certain lectins with selected glycoproteins as well as about the ability of certain monosaccharides to competitively inhibit binding of glycoproteins with lectins. These protein-mediated interactions may be involved in the formulation of self-assembled nanoparticles for therapy and diagnostics of various diseases.

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia

    V. O. Shipunova, M. P. Nikitin, I. V. Zelepukin, S. M. Deyev & R. V. Petrov

  2. Nizhny Novgorod State University, pr. Gagarina 23, Nizhny Novgorod, 603600, Russia

    V. O. Shipunova & S. M. Deyev

  3. Moscow Institute of Physics and Technology (State University), Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700, Russia

    M. P. Nikitin & I. V. Zelepukin

  4. Prokhorov Institute of General Physics, Russian Academy of Sciences, ul. Vavilova 38, Moscow, 119991, Russia

    M. P. Nikitin & P. I. Nikitin

  5. National Research Nuclear University “Moscow Engineering Physics Institute,”, Moscow, Russia

    P. I. Nikitin

Authors
  1. V. O. Shipunova
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  2. M. P. Nikitin
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  3. I. V. Zelepukin
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  4. P. I. Nikitin
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  5. S. M. Deyev
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  6. R. V. Petrov
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Corresponding author

Correspondence to V. O. Shipunova.

Additional information

Original Russian Text © V.O. Shipunova, M.P. Nikitin, I.V. Zelepukin, P.I. Nikitin, S.M. Deyev, R.V. Petrov, 2015, published in Doklady Akademii Nauk, 2015, Vol. 464, No. 4, pp. 501–504.

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Shipunova, V.O., Nikitin, M.P., Zelepukin, I.V. et al. A comprehensive study of interactions between lectins and glycoproteins for the development of effective theranostic nanoagents. Dokl Biochem Biophys 464, 315–318 (2015). https://doi.org/10.1134/S1607672915050117

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  • DOI: https://doi.org/10.1134/S1607672915050117

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