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Aminopyrimidine derivatives as protein kinases inhibitors. Molecular design, synthesis, and biologic activity

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Abstract

The review compiles the strategies and methods of development of aminopyrimidine derivatives as targeted antitumor pharmaceuticals. The advances in organic and heterocyclic chemistry are considered in the targeted synthesis of aminopyrimidine derivatives whose series contains the most demanded and efficient antitrumor pharmaceuticals. The problems of preparation of compounds with multikinase activity profile and the construction of chimeric molecules are discussed.

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Authors and Affiliations

  1. Institute of New Materials Chemistry, National Academy of Sciences of Belarus, ul. F. Skoriny 36, Minsk, 220141, Belarus

    E. V. Koroleva, Zh. I. Ignatovich, Yu. V. Sinyutich & K. N. Gusak

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  1. E. V. Koroleva
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  2. Zh. I. Ignatovich
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  3. Yu. V. Sinyutich
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  4. K. N. Gusak
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Correspondence to E. V. Koroleva.

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Original Russian Text © E.V. Koroleva, Zh.I. Ignatovich, Yu.V. Sinyutich, K.N. Gusak, 2016, published in Zhurnal Organicheskoi Khimii, 2016, Vol. 52, No. 2, pp. 159–196.

Elena Vadimovna Koroleva was born in 1946 in Brest, BSSR. Doctor of chemical sciences, principal researcher of the Institute of New Materials Chemistry, National Academy of Sciences of Belarus. She graduated from the chemical faculty of the Saint-Petersburg (Leningrad) State University in 1968, she was the disciple of Professor B.V. Ioffe. Candidate of chemical sciences since 1974, Doctor of chemical sciences since 1998.

Field of scientific interests: chemistry of heterocyclic compounds of pyrimidine, quinoline, isoxazole, fine organic synthesis.

Zhanna Vladimirovna Ignatovich was born in 1971in Prosvet township, Volzhskii region, Kuibyshev oblast. Candidate of chemical sciences (2010), leading researcher of the Institute of New Materials Chemistry, National Academy of Sciences of Belarus. She graduated from the chemical faculty of the Belorussian State University in 1997.

Field of scientific interests: organic synthesis of heterocyclic compounds.

Yuliya Vyacheslavovna Sinyutich was born in 1989 in Postavy town, Belarus Republic. Post-graduate student of the Institute of New Materials Chemistry, National Academy of Sciences of Belarus. She graduated from the chemical faculty of the Belorussian State University in 2012, Master of chemistry (2013).

Field of scientific interests: chemistry of heterocyclic compounds.

Klavdiya Nikolaevna Gusak was born in 1950 in Shereshevo township, Pruzhanskii region, Brest oblast, BSSR. Candidate of chemical sciences (1981), senior researcher of the Institute of New Materials Chemistry, National Academy of Sciences of Belarus. She graduated from the chemical faculty of the Belorussian State University in 1972.

Field of scientific interests: chemistry of heterocyclic compounds, multicomponent reactions in organic synthesis.

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Koroleva, E.V., Ignatovich, Z.I., Sinyutich, Y.V. et al. Aminopyrimidine derivatives as protein kinases inhibitors. Molecular design, synthesis, and biologic activity. Russ J Org Chem 52, 139–177 (2016). https://doi.org/10.1134/S1070428016020019

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