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Synthesis of Water-Soluble Polyammonium Thiacalix[4]arene Derivative and Its Interaction with Calf Thymus DNA

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Abstract

A water-soluble thiacalix[4]arene derivative containing four diethylenetriamine fragments in 1,3-alternate stereoisomeric form has been obtained for the first time. Using ethidium bromide, it has been found that the macrocycle can interact with calf thymus DNA. The macrocycle has been found to interact with DNA via groove binding. The presence of four diethylenetriamine fragments on the calixarene platform leads to multivalent interactions with DNA, resulting in an increase in the binding constant by two orders of magnitude compared to individual diethylenetriamine.

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Funding

This study was financially supported by the subsidy allocated to Kazan Federal University in the scope of the State Task in the field of research activity (4.1493.2017/4.6, 4.5151.2017/6.7).

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Authors and Affiliations

  1. Kazan (Volga region) Federal University, Kazan, 420008, Russia

    V. A. Burilov, D. A. Mironova, I. A. Grygoriev, A. M. Valiyakhmetova & I. S. Antipin

  2. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”, Kazan, 420088, Russia

    S. E. Solovieva

Authors
  1. V. A. Burilov
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  2. D. A. Mironova
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  3. I. A. Grygoriev
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  4. A. M. Valiyakhmetova
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  5. S. E. Solovieva
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  6. I. S. Antipin
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Corresponding author

Correspondence to V. A. Burilov.

Additional information

To the 80th Anniversary of R.A. Cherkasov

Conflict of Interest

No conflict of interest was declared by the authors.

Russian Text © The Author(s), 2020, published in Zhurnal Obshchei Khimii, 2020, Vol. 90, No. 1, pp. 129–135.

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Burilov, V.A., Mironova, D.A., Grygoriev, I.A. et al. Synthesis of Water-Soluble Polyammonium Thiacalix[4]arene Derivative and Its Interaction with Calf Thymus DNA. Russ J Gen Chem 90, 99–104 (2020). https://doi.org/10.1134/S1070363220010156

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  • DOI: https://doi.org/10.1134/S1070363220010156

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