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Diphenylmethyl and tetrahydropyranyl protecting groups in the synthesis of 3-substituted 5-amino- and 5-hydrazino-1,2,4-triazoles

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Abstract

The use of hydrazine as reagent in nucleophilic substitution and reduction in the 1,2,4-triazole series in combination with introduction of labile protecting groups makes it possible to synthesize 5-hydrazino-3-nitro-1H-1,2,4-triazole and 3-chloro-5-hydrazino-1H-1,2,4-triazol-5-ylhydrazine which were difficultly accessible previously, as well as to extend the series of 3-substituted 5-amino-1H-1,2,4-triazoles.

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Authors and Affiliations

  1. St. Petersburg State Institute of Technology (Technical University), Moskovskii pr. 26, St. Petersburg, 190013, Russia

    V. V. Tolstyakov, I. V. Tselinskii & N. A. Dreving

Authors
  1. V. V. Tolstyakov
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  2. I. V. Tselinskii
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  3. N. A. Dreving
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Correspondence to V. V. Tolstyakov.

Additional information

Original Russian Text V.V. Tolstyakov, I.V. Tselinskii, N.A. Dreving, 2007, published in Zhurnal Obshchei Khimii, 2007, Vol. 77, No. 12, pp. 2034-2040.

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Tolstyakov, V.V., Tselinskii, I.V. & Dreving, N.A. Diphenylmethyl and tetrahydropyranyl protecting groups in the synthesis of 3-substituted 5-amino- and 5-hydrazino-1,2,4-triazoles. Russ J Gen Chem 77, 2179–2185 (2007). https://doi.org/10.1134/S107036320712016X

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  • DOI: https://doi.org/10.1134/S107036320712016X

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