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Synthesis, structure, and activity evaluation of two silver(I) complexes as Helicobacter pylori urease inhibitors

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Abstract

Two silver(I) compounds, [Ag(R,R-hxn)](C7H4BrO2) · 2H2O (I) (Chxn = 1,2-diaminocyclohexane) and [Ag(C5H6N2)2]2(C8H4O4) · 10H2O (II), were synthesized and complex I was structurally characterized by X-ray crystallography. Compound I contains a catena-(trans-1,2-diaminocyclohexane) silver polycation ([Ag(Chxn)]∞) in a roughly linear fashion, while II possesses a linear-type silver monocation. Compounds I and II were evaluated for their inhibitory activities against Helicobacter pylori urease in vitro. Both were found to have strong inhibitory activities against H. pylori urease comparable to that of acetohydroxamic acid.

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Authors and Affiliations

  1. Colloge of Textile, Engineering Research Center for Clean Production of Textile Printing, Ministry of Education, Wuhan Textile University, Wuhan, 430073, P.R. China

    W. Chen, X. L. Xu, P. Zhou, Y. M. Cui & Y. G. Li

Authors
  1. W. Chen
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  2. X. L. Xu
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  3. P. Zhou
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  4. Y. M. Cui
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  5. Y. G. Li
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Corresponding authors

Correspondence to Y. M. Cui or Y. G. Li.

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Chen, W., Xu, X.L., Zhou, P. et al. Synthesis, structure, and activity evaluation of two silver(I) complexes as Helicobacter pylori urease inhibitors. Russ J Coord Chem 39, 301–304 (2013). https://doi.org/10.1134/S1070328413030093

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  • DOI: https://doi.org/10.1134/S1070328413030093

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