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Triterpenoids from the Fruits of Wild Species of Crataegus scabrifolia and Their Lipid-Lowering Activities

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Abstract

To investigate the chemical constituents of fruits of wild species of Crataegus scabrifolia and their lipid-lowering activities. The compounds were isolated and purified by various column chromatography, and their structures were identified based on the comprehensive analyses of the physicochemical properties and spectroscopic data. The lipid-lowering activities of isolated compounds were evaluated by a cellular model of HepG2 in vitro. Ten triterpenoids were obtained from the 95% ethanol extract of the fruits of wild species of C. scabrifolia and identified as α-amyrin (I), ursolic acid (II), pomolic acid (III), tormentic acid (IV), euscaphic acid (V), 2α,19α-dihydroxy-3-oxo-urs-12-en-28-oic acid (VI), fupenzic acid (VII), oleanolic acid (VIII), β-amyrin (IX), and 3-epifriedelinol (X). Compounds (I), (IX), and (X) were isolated from the genus Crataegus for the first time, and compounds (III−VIII) were isolated from the C. scabrifolia for the first time. Compounds (V‒VII) showed significant lipid-lowering activities in vitro with lipid-lowering rates of 8.9 ± 4.3%, 12.0 ± 4.6%, and 6.5 ± 5.5% at a concentration of 200 μmol/L. Molecular docking results suggested that the ACC may be a target of lipid-lowering activity for Crataegus triterpenoids.

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Funding

The work was financially supported by the Special Basic Cooperative Research Programs of Yunnan Provincial Undergraduate Universities’ Association (grant no. 2019FH001-050), the Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan (grant no. 202105AG070003), the Yunnan Fundamental Research Projects (grant no. 202201AT070005), and the Scientific Research Initiation Fund of Dali University for Doctor (grant no. KYBS201734).

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Authors and Affiliations

  1. Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan, 671000, Dali, China

    Qi-Jie Zhu, Li-Juan Lang, Ying Wang, De-Quan Zhang, Bei Jiang & Chao-Jiang Xiao

  2. Institute of Materia Medica, Dali University, 671000, Dali, China

    Qi-Jie Zhu, Li-Juan Lang, Ying Wang, Bei Jiang & Chao-Jiang Xiao

  3. College of Pharmacy, Dali University, 671000, Dali, China

    Qi-Jie Zhu, Li-Juan Lang, Ying Wang, De-Quan Zhang, Bei Jiang & Chao-Jiang Xiao

Authors
  1. Qi-Jie Zhu
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  2. Li-Juan Lang
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  3. Ying Wang
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  4. De-Quan Zhang
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  5. Bei Jiang
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  6. Chao-Jiang Xiao
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Contributions

Chao-Jiang Xiao and Bei Jiang conceptualized the work. Material preparation, extraction and isolation were performed by Qi-Jie Zhu, Ying Wang, and De-Quan Zhang. Biological activity assay was performed by Li-Juan Lang. Molecular docking and the draft of the manuscript were done by Chao-Jiang Xiao.

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Correspondence to Bei Jiang or Chao-Jiang Xiao.

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This article does not contain any studies involving animals or human participants performed by any of the authors.

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The authors declare that they have no conflicts of interest.

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Qi-Jie Zhu, Lang, LJ., Wang, Y. et al. Triterpenoids from the Fruits of Wild Species of Crataegus scabrifolia and Their Lipid-Lowering Activities. Russ J Bioorg Chem 48, 1291–1298 (2022). https://doi.org/10.1134/S1068162022060292

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  • DOI: https://doi.org/10.1134/S1068162022060292

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