Abstract
Oxadiazoles are heterocyclic compounds in numerous approved, and experimental drugs, bioactive molecules, liquid crystals, diodes and in solar cell applications. It is one of the primary molecules studied in recent times and is a vital molecule employed in medicinal-chemistry for the preparation of anticancer, anti-HIV, anti-TB, anti-hepatitis etc. Research in the chemistry of the oxadiazole derivatives has been developed with the evolution of each application area and the need for target molecules with specific properties. A large number of in vivo applications for the oxadiazole analogues have also been performed. Presently, it has also been introduced as both auxiliary acceptor and spacer in dye-sensitized solar cell study with significant efficiency. Extensive literature has been documented the different applications of this versatile scaffold. The current review described some critical synthetic approaches to form such a vital moiety along with its derivatives and discussed its diverse applications, which includes the moiety in pharmacological activities, diode, liquid crystal, and solar cell fields. The review also describes some advancement in the field from our group, and also, the scope of the further study has been introduced.
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The authors are thankful to the GITAM (Deemed to be University) for providing instrumental and computational facilities.
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We thank the Department of Science and Technology, India, under DST-FIST Program 2014 with project no. SR/FST/ETI-373/2016.
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Anjali Jha and Anik Sen contributed equally to the study.
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Anjali Jha, Sen, A. & Malla, R.R. Chemistry of Oxadiazole Analogues: Current Status and Applications. Russ J Bioorg Chem 47, 670–680 (2021). https://doi.org/10.1134/S1068162021030092
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DOI: https://doi.org/10.1134/S1068162021030092