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Structural features of cysteine-rich polypeptides from sea anemone venoms

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Abstract

At present, the discovery of drugs based on animal venoms undergoes its rebirth: pharmaceutical companies start to accept gradually the potential of animal venoms as combinatorial libraries of biologically active compounds. Sea anemones are a group of animals that produce the most structurally versatile polypeptide venom components, which distinguish them from the majority of other venomous animals. The known polypeptide toxins from the sea anemone venoms are considered in this review primarily in terms of their classification according to structural features. The most outstanding functional features of polypeptides within each class were analyzed.

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Abbreviations

ICK:

Inhibitor Cystine Knot

SRDA:

Single Residue Distribution Analysis

PDB:

Protein Data Bank

pBLAST:

protein Basic Local Alignment Search Tool

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia

    A. N. Mikov & S. A. Kozlov

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  1. A. N. Mikov
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  2. S. A. Kozlov
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Correspondence to A. N. Mikov.

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Article is based on materials presented at VII Russian Symposium “Proteins and Peptides,” Novosibirsk, July 12–17, 2015.

Original Russian Text © A.N. Mikov, S.A. Kozlov, 2015, published in Bioorganicheskaya Khimiya, 2015, Vol. 41, No. 5, pp. 511–523.

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Mikov, A.N., Kozlov, S.A. Structural features of cysteine-rich polypeptides from sea anemone venoms. Russ J Bioorg Chem 41, 455–466 (2015). https://doi.org/10.1134/S1068162015050088

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