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Synthesis of aminopropylamino derivatives of betulinic and oleanolic acids

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Abstract

Triterpenoids with the following amine fragments in C3 and C28 positions were synthesized on the basis of betulinic and oleanolic acids: (3-aminopropoxy)-, 3-acetyl-(3-aminopropyl)amino-, 6-[bis(3-aminopropyl)amino]hexylamino-, and (3-aminopropyl)-4-aminophenylsulfonyl-4-phenylamino. Amide of betulonic acid with 4,4′-diaminodiphenylsulfonic substituent was shown to exhibit no antitumor effect, but to have a pronounced anti-inflammatory activity.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Ufa Research Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 45054, Russia

    G. V. Giniyatullina, O. B. Kazakova & N. I. Medvedeva

  2. Vorozhtsov Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent’eva 9, Novosibirsk, 630090, Russia

    I. V. Sorokina, N. A. Zhukova, T. G. Tolstikova & G. A. Tolstikov

Authors
  1. G. V. Giniyatullina
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  2. O. B. Kazakova
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  3. N. I. Medvedeva
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  4. I. V. Sorokina
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  5. N. A. Zhukova
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  6. T. G. Tolstikova
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  7. G. A. Tolstikov
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Corresponding author

Correspondence to O. B. Kazakova.

Additional information

Original Russian Text © G.V. Giniyatullina, O.B. Kazakova, N.I. Medvedeva, I.V. Sorokina, N.A. Zhukova, T.G. Tolstikova, G.A. Tolstikov, 2013, published in Bioorganicheskaya Khimiya, 2013, Vol. 39, No. 3, pp. 369–377.

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Giniyatullina, G.V., Kazakova, O.B., Medvedeva, N.I. et al. Synthesis of aminopropylamino derivatives of betulinic and oleanolic acids. Russ J Bioorg Chem 39, 329–337 (2013). https://doi.org/10.1134/S1068162013020064

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  • DOI: https://doi.org/10.1134/S1068162013020064

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