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Structural transformations of arabinogalactan from the Siberian larch during mechanochemical processing and the biological properties of the products

  • Plant Biopolymers
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Abstract

It has been found by gel-penetrating chromatography and quantitative 13C NMR spectroscopy that mechanochemical processing of arabinogalactan isolated from the wood of the Siberian larch changes the molecular mass distribution, monosaccharide composition, and the degree of branching of its macromolecules. This is due to the partial destruction of polysaccharide macromolecules and subsequent recombination of resulting fragments. The intensity of these processes depends on the conditions of mechanochemical processing. Based on the data of IR and 13C NMR spectra, the conclusion has been drawn that no functionalization of arabinogalactan macromolecules occurs under these conditions. The toxicopharmacological properties of mechanically processed arabinogalactan have been studied. Its acute toxicity is >5000 mg/kg.

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Abbreviations

AG:

arabinogalactan

AP:

arterial pressure

ECG:

electrocardiogram

GPC:

gel-penetrating chromatography

MMD:

molecular mass distribution

References

  1. Krishtanova, N.A., Safonova, M.Yu., and Bolotova, V.Ts., Vestnik VGU. Seriya Khim. Biol. Farmats., 2005, no. 1, pp. 212–221.

  2. Medvedeva, E.N., Babkin, V.A., and Ostroukhova, L.A., Khim. Rastit. Syr’ya, 2003, no. 1, pp. 27–37.

  3. Medvedeva, S.A. and Aleksandrova, G.P., in Panorama sovremennoi khimii Rossii. Sintez i modifikatsiya polimerov (An Overview of Modern Chemistry of Russia: Synthesis and Modification of Polymers), Moscow, 2003, pp. 328–356.

  4. Badykova, L.A., Interaction of Arabinogalactan of Siberian Larch with 4-Aminosalycilic Acid, 4-Aminosalycilic Acid, and Isonicotinic Acid Hydrazide, Extended Abstract of Cand. Sci. (Chem.) Dissertation, Ufa, 2007.

  5. Badykova, L.A., Mudarisova, R.Kh., Borisov, I.M., and Monakov, Yu.B., in Khimiya i tekhnologiya rastitel’nykh veshchestv: tez. dokl. IV Vseross. nauchn. konf. (Chemistry and Technology of Plant Substances, Abstr. IV All-Russia Sci. Conf.), Syktyvkar, 2006, p. 29.

  6. Koptyaeva, E.I. and Mudarisova, R.Kh., in Khimiya i meditsina: tez. dokl. VI Vseross. nauchn. seminara (Chemistry and Medicine, Abstr. VI All-Russia Sci. Workshop), Ufa, 2007, p. 171.

  7. Domb, A.J., Benita, S., Polachek, I., and Linden, G., US Patent no. 6 011 008, CA 2000, vol. 132, p. 69331.

  8. Nogawa, M., Akaike, T., and Maruyama, A., S.T.P. Pharma Sci., 2001, vol. 11, no. 1, pp. 91–102.

    Google Scholar 

  9. Assam, T., Eliyahu, H., Shapira, L., Linial, M., Barenholz, Y., and Domb, A.J., J. Med. Chem., 2002, vol. 45, no. 9, pp. 1817–1824.

    Article  Google Scholar 

  10. Ehrenfreund-Kleinman, T., Azzam, T., Falk, R., Golenser, J., and Domb, A.J., Biomaterials, 2002, vol. 23, no. 5, pp. 1327–1335.

    Article  CAS  PubMed  Google Scholar 

  11. Josephson, L., Rutkowski, J.V., Paul, K., Frugo, T., and Groman, E.V., Antiviral Therapy, 1996, vol. 1, no. 3, pp. 147–156.

    CAS  PubMed  Google Scholar 

  12. Sukhov, B.G., Aleksandrova, G.P., Ganenko, T.V., Grishchenko, L.A., et al., in Khimiya i medichina: tez. dokl. VI Vseross. nauchn. seminara (Chemistry and Medicine, Abstr. VI All-Russia Sci. Workshop), Ufa, 2007, pp. 95–96.

  13. Grishchenko, L.A., Metal-Containing Nanocomposites on the Basis of Arabinogalactan, Cand. Sci. (Chem.) Dissertation, Irkutsk, 2007.

  14. Shirokova, E.N., Oxidation of Arabinogalactan in the Presence of Hydrogen Peroxide and Potassium Persulfate in Aqueous Medium, Extended Abstract of Cand. Sci. (Chem.) Dissertation, Ufa, 2003.

  15. Mudarisova, R.Kh., Shirokova, E.N., Badykova, L.A., Borisov, I.M., et al., Khim.-Farm. Zh., 2005, vol. 39, no. 8, pp. 23–26.

    Google Scholar 

  16. Badykova, L.A., Mudarisova, R.Kh., Tolstikova, T.G., Borisov, I.M., and Monakov, Yu.B., Khim. Prir. Soedin., 2005, no. 3, pp. 219–222.

  17. Mudarisova, R.Kh., Badykova, L.A., Tolstikova, T.G., Aleksandrova, G.P., et al., Zh. Prikl. Khim., 2005, vol. 78, no. 10, pp. 1721–1724.

    Google Scholar 

  18. Meteleva, E.S., Dushkin, A.V., Tolstikova, T.G., Tolstikov, G.A., et al., in Khimiya i meditsina: tez. dokl. VI Vseross. nauchn. seminara (Chemistry and Medicine, Abstr. VI All-Russia Sci. Workshop), Ufa, 2007, pp. 189–190.

  19. Dubinskaya, A.M., Usp. Khim., 1999, no. 68, pp. 708–724.

  20. Medvedeva, E.N., Babkin, V.A., Makarenko, O.A., Nikolaev, S.M., et al., Khim. Rastit. Syr’ya, 2004, no. 4, pp. 17–23.

  21. Babkin, V.A., Kolzunova, L.G., Medvedeva, E.N., Malkov, Yu.A., and Ostroukhova, L.A., RF Patent no. 2256668, Byul. Izobret., 2005, no. 20.

  22. Dubois, M., Gilles, K.A., Hamilton, J.K., Rebers, P.A., and Smith, F., Anal. Chem., 1956, vol. 28, no. 3, pp. 350–356.

    Article  CAS  Google Scholar 

  23. Fedorova, T.E., 13S, 17O NMR Quantitative Spectroscopy and Physiologicla Activity of Humic Acids, Extended Abstract of Cand. Sci. (Chem.) Dissertation, Irkutsk, 2000.

  24. Medvedeva, E.N., Fedorova, T.E., Vanina, A.S., Rokhin, A.V., et al., Khim. Rastit. Syr’ya, 2006, no. 1, pp. 25–32.

  25. Antonova, G.F. and Tyukavkina, N.A., Khim. Drev., 1976, no. 4, pp. 60–62.

  26. Karacsonyi, S., Kovacik, V., Alfoldi, J., and Kubackova, M., Carbohydr. Res., 1984, vol. 134, pp. 265–274.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Favorskii Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, ul. Favorskogo 1, Irkutsk, 664033, Russia

    E. N. Medvedeva, N. A. Neverova, T. E. Fedorova & V. A. Babkin

  2. Institute of Chemistry of Solid Body and Mechanochemistry, Siberian Branch, Russian Academy of Sciences, ul. Kutateladze 18, Novosibirsk, 630128, Russia

    E. S. Meteleva & A. V. Dushkin

  3. Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent’eva 9, Novosibirsk, 630090, Russia

    T. G. Tolstikova, M. V. Khvostov & M. P. Dolgikh

Authors
  1. E. N. Medvedeva
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  2. N. A. Neverova
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  3. T. E. Fedorova
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  4. V. A. Babkin
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  5. E. S. Meteleva
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  6. A. V. Dushkin
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  7. T. G. Tolstikova
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  8. M. V. Khvostov
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  9. M. P. Dolgikh
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Correspondence to E. N. Medvedeva.

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Original Russian Text © E.N. Medvedeva, N.A. Neverova, T.E. Fedorova, V.A. Babkin, E.S. Meteleva, A.V. Dushkin, T.G. Tolstikova, M.V. Khvostov, M.P. Dolgikh, 2010, published in Khimiya Rastitel’nogo Syr’ya, 2009, No. 3, pp. 49–56.

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Medvedeva, E.N., Neverova, N.A., Fedorova, T.E. et al. Structural transformations of arabinogalactan from the Siberian larch during mechanochemical processing and the biological properties of the products. Russ J Bioorg Chem 36, 853–859 (2010). https://doi.org/10.1134/S1068162010070101

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  • DOI: https://doi.org/10.1134/S1068162010070101

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