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Positively charged acyl derivatives of carbohydrates as promising transfection agents

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Abstract

A convenient approach to the synthesis of mono-and polycationic glycolipid amphiphiles is suggested. The compounds obtained can be used for studying the structure-activity relationship and determination of the effect of hydrophobic and cationic domains on the transfection efficiency.

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Abbreviations

ADP:

1,1′-(azodicarbonyl)dipiperidine

CDI:

1,1′-carbonyldiimidazole

DEAD:

diethylazodicarbohylate

DIAD:

diizopropylazodicarboxylate

DMAP:

N,N-dimethylaminopyridine

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Authors and Affiliations

  1. Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 119571, Russia

    M. A. Maslov, Z. Ya. Al Shoaibi, T. V. Andryushina, N. G. Morozova & G. A. Serebrennikova

Authors
  1. M. A. Maslov
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  2. Z. Ya. Al Shoaibi
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  3. T. V. Andryushina
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  4. N. G. Morozova
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  5. G. A. Serebrennikova
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Corresponding author

Correspondence to M. A. Maslov.

Additional information

Original Russian Text © M.A. Maslov, Z.Ya. Al Shoaibi, T.V. Andryushina, N.G. Morozova, G.A. Serebrennikova, 2007, published in Bioorganicheskaya Khimiya, 2007, Vol. 33, No. 5, pp. 538–543.

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Maslov, M.A., Al Shoaibi, Z.Y., Andryushina, T.V. et al. Positively charged acyl derivatives of carbohydrates as promising transfection agents. Russ J Bioorg Chem 33, 499–504 (2007). https://doi.org/10.1134/S1068162007050068

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  • DOI: https://doi.org/10.1134/S1068162007050068

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