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Artificial inhibition of the complement system

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Abstract

A great number of natural substances affect the complement system in addition to its natural regulators. Among the complement effectors, the most important are inhibitors of the activation cascade. The necessity of searching for preparations capable of a purposeful effect on complement by inhibition of single stages of the activation cascade and without influence on its other functions is connected with the current importance of use in medicine of novel therapeutic regulators of the complement system. Important directions are the search for complement inhibitors that (a) interfere with the rejection of transplants; (b) can replace C1 inhibitor in hereditary angioedema; and (c) have a high anti-inflammatory activity in the therapy of rheumatic diseases, diabetes, and other autoimmune disorders. It is expedient to use the available techniques for the directed detection of the action of medicinal substances on complement, which allow the determination of their action on the complement system at various stages of the cascade of its activation.

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References

  1. Belkin, Z.P., Kozlov, L.V., Andina, S.S., Mishin, A.A., Guzova, V.A., and D’yakov, V.L., Vopr. Med. Khim., 2002, vol. 48, pp. 373–377.

    PubMed  CAS  Google Scholar 

  2. Andina, S.S., Kozlov, L.V., and D’yakov, V.L., Biomed. Khim., 2004, vol. 50, pp. 86–91.

    PubMed  CAS  Google Scholar 

  3. Weisman, H.F., Bartow, T., Leppo, M.K., Boyle, M.P., Marsh, H.C., Jr., Carson, G.R., Roux, K.H., Weisfeldt, M.L., and Fearon, D.T., Trans. Assoc. Am. Physicians, 1990, vol. 103, pp. 64–72.

    PubMed  CAS  Google Scholar 

  4. Levin, J.L., Marsh, H.C., Jr., and Rudolph, A.R., Landes Company, Texas, 1996, pp. 695–702.

  5. Marsh, H.C. and Ryan, U.S., in The Trandplatarion of Organs and Tissues between Species, Cooper DKC, 2nd ed., Kemp, E., Platt, J.L., and White, D.J.G., Eds., Berlin: Springer, 1997, pp. 437–455.

    Google Scholar 

  6. Dellinger, R.P., Zimmerman, J.L., Straube, R.C., Metzler, M.H., Wall, M., Brown, B.K., Levin, J.L., Toth, C.A., and Ryan, U.S., Crit. Care. Med., 1996, vol. 24, p. 29.

    Google Scholar 

  7. Picard, M.D., Pettey, C.L., Marsh, H.C., Jr., and Thomas, L.J., Glycobiology, 1996, vol. 6, p. 766.

    Google Scholar 

  8. Scesney, S.M., Makrides, S.C., Gosselin, M.L., Ford, P.J., Andrews, B.M., Hayman, E.G., and Marsh, H.C., Jr., Eur. J. Immunol., 1996, vol. 26, pp. 1729–1735.

    PubMed  CAS  Google Scholar 

  9. Gralinski, M.R., Wiater, B.C., Assenmacher, A.N., and Lucchesi, B.R., Immunopharmacology, 1996, vol. 34, pp. 79–88.

    PubMed  CAS  Google Scholar 

  10. Lennon, P.F., Collard, C.D., Morrissey, M.A., and Stahl, G.L., Am. J. Physiol., 1996, vol. 270, pp. 1924–1932.

    Google Scholar 

  11. Murohara, T., Guo, J., Delyani, J.A., and Lefer, A.M., Methods. Find. Exp. Clin. Pharmacol., 1995, vol. 17, pp. 499–507.

    PubMed  CAS  Google Scholar 

  12. Marsh, H., New Therapeutic Targets Based on Control of Complement System,, 1997, June 9–11, Boston, MA.

  13. Sugita, Y., Ito, K., Shiozuka, K., Suzuki, H., Gushima, H., Tomita, M., and Masuho, Y., Immunology, 1994, vol. 82, pp. 34–41.

    PubMed  CAS  Google Scholar 

  14. Suzuki, H., Yamaji, N., Egashira, A., Yasunaga, K., Sugita, Y., and Masuho, Y., FEBS Lett., 1996, vol. 399, pp. 272–276.

    PubMed  CAS  Google Scholar 

  15. Christiansen, D., Milland, J., Thorley, B.R., McKenzie, I.F.C., and Loveland, B.E., Eur. J. Immunol., 1996, vol. 26, pp. 578–585.

    PubMed  CAS  Google Scholar 

  16. Buerke, M., Murohara, T., and Lefer, A.M., Circulation, 1995, vol. 91, pp. 393–402.

    PubMed  CAS  Google Scholar 

  17. Horstick, G., Heimann, A., Gotze, O., Hafner, G., Berg, O., Boehmer, P., Becker, P., Darius, H., Rupprecht, H.J., Loos, M., Bhakdi, S., Meyer, J., and Kempski, O., Circulation, 1997, vol. 95, pp. 701–708.

    PubMed  CAS  Google Scholar 

  18. Murohara, T., Guo, J.P., and Lefer, A.M., J. Pharmacol. Exp. Ther., 1995, vol. 274, pp. 1246–1253.

    PubMed  CAS  Google Scholar 

  19. Iwata, K., Seya, T., Ariga, H., and Nagasawa, S., J. Immunol., 1994, vol. 152, pp. 3436–3444.

    PubMed  CAS  Google Scholar 

  20. Higgins, P.J., Ko, J.L., Lobell, R., Sardonini, C., Alessi, M.K., and Yeh, C.G., J. Immunol., 1997, vol. 158, pp. 2872–2881.

    PubMed  CAS  Google Scholar 

  21. Fodor, W.L., Rollins, S.A., Guilmette, E.R., Setter, E., and Squinto, S.P., J. Immunol., 1995, vol. 155, pp. 4135–4138.

    PubMed  CAS  Google Scholar 

  22. Rinder, C.S., Rinder, H.M., Smith, B.R., Fitch, J.C., Smith, M.J., Tracey, J.B., Matis, L.A., Squinto, S.P., and Rollins, S.A., J. Clin. Invest., 1995, vol. 96, pp. 1564–1572.

    PubMed  CAS  Google Scholar 

  23. Wurzner, R., Schulze, M., Happe, L., Franzke, A., Bieber, F.A., Oppermann, M., and Gotze, O., Complement. Inflamm., 1991, vol. 8, pp. 328–340.

    PubMed  CAS  Google Scholar 

  24. Evans, M.J., Rollins, S.A., Wolff, D.W., Rother, R.P., Norin, A.J., Therrien, D.M., Grijalva, G.A., Mueller, J.P., Nye, S.H., Squinto, S.P., and Wilkins, J.A., Mol. Immunol., 1995, vol. 32, pp. 1183–1195.

    PubMed  CAS  Google Scholar 

  25. Thomas, T.C., Rollins, S.A., Rother, R.P., Giannoni, M.A., Hartman, S.L., Elliott, E.A., Nye, S.H., Matis, L.A., Squinto, S.P., and Evans, M.J, Mol. Immunol., 1996, vol. 33, pp. 1389–1401.

    PubMed  CAS  Google Scholar 

  26. van den Berg, R.H., Faber-Krol, M., van Es, L.A., and Daha, M.R., Eur. J. Immunol., 1995, vol. 25, pp. 2206–2210.

    PubMed  Google Scholar 

  27. van Oostrum, J., van Heeke, G., and Schmitz, A., Patent WO, 96/39503. 1996.

  28. Gonzalez-Rubio, C., Jimenez-Clavero, M.A., Fontan, G., and Lopez-Trascasa, M., J. Biol. Chem., 1994, vol. 269, pp. 26017–26024.

    PubMed  CAS  Google Scholar 

  29. Lopez-Trascasa, M., Bing, D.H., Rivard, M., and Nicholson-Weller, A., J. Biol. Chem., 1989, vol. 264, pp. 16 214–16 221.

    CAS  Google Scholar 

  30. Homeister, J.W. and Lucchesi, B.R., Annu. Rev. Pharmacol. Toxicol., 1994, vol. 34, pp. 17–40.

    PubMed  CAS  Google Scholar 

  31. Shandelya, S.M.L., Kuppusamy, P., Herskowitz, A., Weisfeldt, M.L., and Zweier, J.L., Circulation, 1993, vol. 88, pp. 2812–2826.

    PubMed  CAS  Google Scholar 

  32. Pemberton, M., Anderson, G., Vetvicka, V., Justus, D.E., and Ross, G.D., J. Immunol., 1993, vol. 150, p. 5104.

    PubMed  CAS  Google Scholar 

  33. Chavez-Cartaya, R., Cozzi, E., Pino-DeSola G., Jamieson N.V., and White, D.J., Transplant. Proc., 1995, vol. 27, pp. 2852–2854.

    PubMed  CAS  Google Scholar 

  34. Mulligan, M.S., Yeh, C.G., Rudolph, A.R., and Ward, P.A., J. Immunol., 1992, vol. 148, pp. 1479–1485.

    PubMed  CAS  Google Scholar 

  35. Pratt, J.R., Hibbs, M.J., Laver, A.J., Smith, R.A.G., and Sacks, S.H., Am. J. Pathol., 1996, vol. 149, pp. 2055–2066.

    PubMed  CAS  Google Scholar 

  36. Makrides, S.C., Nygren, P.A., Andrews, B., Ford, P.J., Evans, K.S., Hayman, E.G., Adari, H., Levin, J., Uhlen, M., and Toth, C.A., J. Pharmacol. Exp. Ther., 1996, vol. 277, pp. 534–542.

    PubMed  CAS  Google Scholar 

  37. Kalli, K.R., Hsu, P.H., Bartow, T.J., Ahearn, J.M., Matsumoto, A.K., Klickstein, L.B., and Fearon, D.T., J. Exp. Med., 1991, vol. 174, pp. 1451–1460.

    PubMed  CAS  Google Scholar 

  38. Capon, D.J., Chamow, S.M., Mordenti, J., Marsters, S.A., Gregory, T., Mitsuya, H., Byrn, R.A., Lucas, C., Wurm, F.M., Groopman, J.E., Broder, S., and Smith, D.H., Nature, 1989, vol. 337, pp. 525–531.

    PubMed  CAS  Google Scholar 

  39. Kalli, K.R., Hsu, P., and Fearon, D.T., Springer Semin. Immunopathol., 1994, vol. 15, pp. 417–431.

    PubMed  CAS  Google Scholar 

  40. Morrison, S.L. and Shin, S.U., Advanced Drug Delivery. Rev., 1995, vol. 15, pp. 147–175.

    CAS  Google Scholar 

  41. Morgan, B.P., Immunol. Today, 1995, vol. 16, pp. 257–259.

    PubMed  CAS  Google Scholar 

  42. Haviland, D.L., McCoy, R.L., Whitehead, W.T., Akama, H., Molmenti, E.P., Brown, A., Haviland, J.C., Parks, W.C., Perlmutter, D.H., and Wetsel, R.A., J. Immunol., 1995, vol. 154, pp. 1861–1869.

    PubMed  CAS  Google Scholar 

  43. Crass, T., Raffetseder, U., Martin, U., Grove, M., Klos, A., Kohl, J., and Bautsch, W., Eur. J. Immunol., 1996, vol. 26, pp. 1944–1950.

    PubMed  CAS  Google Scholar 

  44. Ward, P.A., Am. J. Pathol., 1996, vol. 149, pp. 1081–1086.

    PubMed  CAS  Google Scholar 

  45. Ross, S.C. and Densen, P., Medicine, 1984, vol. 63, pp. 243–273.

    PubMed  CAS  Google Scholar 

  46. Homeister, J.W., Satoh, P., and Lucchesi, B.R., Circ. Res., 1992, vol. 71, pp. 303–319.

    PubMed  CAS  Google Scholar 

  47. Mulligan, M.S., Schmid, E., and Till, G.O., Hugh O.A., Friedl H.P., Roth R.A., Ward P.A, J. Immunol., 1997, vol. 158, pp. 1857–1861.

    PubMed  CAS  Google Scholar 

  48. Kasturi, L., Chen, H.G., and Shakin-Eshleman, S.H., Biochem. J., 1997, vol. 323, pp. 415–419.

    PubMed  CAS  Google Scholar 

  49. Moore, M.D., Cooper, N.R., Tack, B.F., and Nemerow, G.R., Proc. Natl. Acad. Sci. USA, 1987, vol. 84, pp. 9194–9198.

    PubMed  CAS  Google Scholar 

  50. Weis, J.J., Toothaker, L.E., Smith, J.A., Weis, J.H., and Fearon, D.T., J. Exp. Med., 1988, vol. 167, pp. 1047–1066.

    PubMed  CAS  Google Scholar 

  51. Dempsey, P.W., Allison, M.E.D., Akkaraju, S., Goodnow, C.C., and Fearon, D.T., Science, 1996, vol. 271, pp. 348–350.

    PubMed  CAS  Google Scholar 

  52. Byrne, G.W., McCurry, K.R., Martin, M.J., McClellan, S.M., Platt, J.L., and Logan, J.S., Transplantation, 1997, vol. 63, pp. 149–155.

    PubMed  CAS  Google Scholar 

  53. Miyagawa, S., Shirakura, R., Izutani, H., Matsumiya, G., Nakata, S., Matsuda, H., Iwata, K., Nagasawa, S., Terado, A., Matsumoto, M., and Seya, T., Transplant. Proc., 1994, vol. 26, pp. 1253–1254.

    PubMed  CAS  Google Scholar 

  54. Makrides, S.C., Ryan, U.S., and Blackwell, Science, 1997, p. 425.

  55. Wang, Y., Rollins, S.A., Madri, J.A., and Matis, L.A., Proc. Natl. Acad. Sci. USA, 1995, vol. 92, pp. 8955–8959.

    PubMed  CAS  Google Scholar 

  56. Vogt, W., Damerau, B., von Zabern, I., Nolte, R., and Brunahl, D., Mol. Immunol., 1989, vol. 26, pp. 1133–1142.

    PubMed  CAS  Google Scholar 

  57. Wetsel, R.A. and Kolb, W.P., J. Exp. Med., 1983, vol. 157, pp. 2029–2048.

    PubMed  CAS  Google Scholar 

  58. Wang, Y., Hu, Q.L., Madri, J.A., Rollins, S.A., Chodera, A., and Matis, L.A., Proc. Natl. Acad. Sci. USA, 1996, vol. 93, pp. 8563–8568.

    PubMed  CAS  Google Scholar 

  59. Khazaeli, M.B., Conry, R.M., and LoBuglio, A.F., J. Immunother., 1994, vol. 15, pp. 42–52.

    CAS  Google Scholar 

  60. Fishwild, D.M., O’Donnell, S, Bengoechea, T., Hudson, D.V., Harding, F., Bernhard, S.L., Jones, D., Kay, R.M., Higgins, K.M., Schramm, S.R., and Lonberg, N., Nat. Biotechnol., 1996, vol. 14, pp. 845–851.

    PubMed  CAS  Google Scholar 

  61. Berrens, L., de la Cuadra, B., and Gallego, M.T., Life Sci., 1997, vol. 60, pp. 1497–1503.

    PubMed  CAS  Google Scholar 

  62. Kroes, B.H., Beukelman, C.J., Berg, A.J.J., Wolbink, G.J., van Dijk, H., and Labadie, R.P., Immunology, 1997, vol. 90, pp. 115–120.

    PubMed  CAS  Google Scholar 

  63. Zhao, J.F., Kiyohara, H., Yamada, H., Takemoto, N., and Kawamura, H., Carbohydr. Res., 1991, vol. 219, pp. 149–172.

    PubMed  CAS  Google Scholar 

  64. Gonda, R., Tomoda, M., Shimizu, N., and Yamada, H., Carbohydr. Res., 1990, vol. 198, pp. 323–329.

    PubMed  CAS  Google Scholar 

  65. Yamada, H., Kiyohara, H., Cyong, J.C., and Otsuka, Y., Carbohydr. Res., 1987, vol. 159, pp. 275–291.

    PubMed  CAS  Google Scholar 

  66. Englberger, W., Hadding, U., Etschenberg, E., Graf, E., Leyck, S., Winkelmann, J., and Parnham, M.J., Int. J. Immunopharmacol., 1988, vol. 10, pp. 729–737.

    PubMed  CAS  Google Scholar 

  67. Ling, M., Piddlesden, S.J., and Morgan, B.P., Clin. Exp. Immunol., 1995, vol. 102, pp. 582–588.

    Article  PubMed  CAS  Google Scholar 

  68. Locher, C.P., Burch, M.T., Mower, H.F., Berestecky, J., Davis, H., van Poel, B., Lasure, A., van den Berghe, D.A., and Vlietinck, A.J., J. Ethnopharmacol., 1995, vol. 49, pp. 23–32.

    PubMed  CAS  Google Scholar 

  69. Ivanovska, N. and Philipov, S., Int. J. Immunopharmacol., 1996, vol. 18, pp. 553–561.

    PubMed  CAS  Google Scholar 

  70. Ivanovska, N., Iossifova, T., and Kostova, I., Phytotherapy. Res, 1996, vol. 10, pp. 555–558.

    CAS  Google Scholar 

  71. Gao, Q., Kiyohara, H., Cyong, J., and Yamada, H., Planta Med., 1989, vol. 55, pp. 9–12.

    PubMed  CAS  Google Scholar 

  72. Yamada, H., Ra, K.S., Kiyohara, H., Cyong, J.C., Yang, H.C., and Otsuka, Y., Phytochemistry, 1988, vol. 27, pp. 3163–3168.

    CAS  Google Scholar 

  73. Popescu, C., Croitoru, M., and Gancevici, G.G., Arch. Roum. Pathol. Exp. Microbiol., 1988, vol. 47, pp. 37–41.

    PubMed  CAS  Google Scholar 

  74. Gancevici, G.G. and Popescu, N., Arch. Roum. Pathol. Exp. Microbiol., 1987, vol. 46, pp. 321–331.

    PubMed  CAS  Google Scholar 

  75. Kosasi, S., Hart, L.A., van Dijk, H., and Labadie, R.P., J. Ethnopharmacol., 1989, vol. 27, pp. 81–89.

    PubMed  CAS  Google Scholar 

  76. Blondin, C., Fischer, E., Boisson-Vidal, C., Kazatchkine, M.D., and Jozefonvicz, J., Mol. Immunol., 1994, vol. 31, pp. 247–253.

    PubMed  CAS  Google Scholar 

  77. Charreau, B., Blondin, C., Boisson-Vidal, C., Soulillou, J.P., and Anegon, I., Transplant. Proc., 1997, vol. 29, pp. 889–890.

    PubMed  CAS  Google Scholar 

  78. Washburn, R.G., De Hart, D.J., Agwu, D.E., Bryant-Varela, B.J., and Julian, E.N., Infect. Immun., 1990, vol. 58, pp. 3508–3515.

    PubMed  CAS  Google Scholar 

  79. Kaneko, I., Kamoshida, K., and Takahashi, S., J. Antibiot., 1989, vol. 42, pp. 236–241.

    PubMed  CAS  Google Scholar 

  80. Seto, H., Fujioka, T., Furihata, K., Kaneko, I., and Takahashi, S., Tetrahedron. Lett., 1989, vol. 30, pp. 4987–4990.

    CAS  Google Scholar 

  81. Kitano, A., Matsumoto, T., Nakamura, S., Obata, A., Oshitani, N., Okawa, K., and Kobayashi, E., Dis. Colon. Rectum, 1992, vol. 35, pp. 560–567.

    PubMed  CAS  Google Scholar 

  82. Miyagawa, S., Shirakura, R., Matsumiya, G., Fukushima, N., Nakata, S., Matsuda, H., Matsumoto, M., Kitamura, H., and Seya, T., Transplantation, 1993, vol. 55, pp. 709–713.

    PubMed  CAS  Google Scholar 

  83. Miyazaki, W., Tamaoka, H., Shinohara, M., Kaise, H., Izawa, T., Nakano, Y., Kinoshita, T., Hong, K., and Inoue, K., Microbiol. Immunol., 1980, vol. 24, pp. 1091–1108.

    PubMed  CAS  Google Scholar 

  84. Kobayashi, T., Neethling, F.A., Taniguchi, S., Ye, Y., Niekrasz, M., Koren, E., Hancock, W.W., Takagi, H., and Cooper, D.K.C., Xenotransplantation, 1996, vol. 3, pp. 237–245.

    Google Scholar 

  85. Krumdieck, R., Hook, M., Rosenberg, L.C., and Volanakis, J.E., J. Immunol., 1992, vol. 149, pp. 3695–3701.

    PubMed  CAS  Google Scholar 

  86. Linhardt, R.J., Rice, K.G., Kim, Y.S., Engelken, J.D., and Weiler, J.M., J. Biol. Chem., 1988, vol. 263, pp. 13090–13096.

    PubMed  CAS  Google Scholar 

  87. Maillet, F., Kazatchkine, M.D., Glotz, D., Fischer, E., and Rowe, M., Mol. Immunol., 1983, vol. 20, pp. 1401–1404.

    PubMed  CAS  Google Scholar 

  88. te Velthuis, H., Jansen, P.G., Hack, C.E., Eijsman, L., and Wildevuur, C.R., Ann. Thorac. Surg., 1996, vol. 61, pp. 1153–1157.

    Google Scholar 

  89. Gralinski, M.R., Park, J.L., Ozeck, M.A., Wiater, B.C., and Lucchesi, B.R., J. Pharmacol. Exp. Ther., 1997, vol. 282, pp. 554–560.

    PubMed  CAS  Google Scholar 

  90. Wuillemin, W.A., Velthuis, H., Lubbers, Y.T.P., de Ruig, C.P., Eldering, E., and Hack, C.E., J. Immunol, 1997, vol. 159, pp. 1953–1960.

    PubMed  CAS  Google Scholar 

  91. Quigg, R.J., Immunology, 1992, vol. 76, pp. 373–377.

    PubMed  CAS  Google Scholar 

  92. Kirschfink, M., Blase, L., Engelmann, S., and Schwartz-Albiez, R., J. Immunol., 1997, vol. 158, pp. 1324–1331.

    PubMed  CAS  Google Scholar 

  93. Georgieva, P., Ivanovska, N., Bankova, V., and Popov, S., Z. Naturforsch., A: Phys. Sci., 1997, vol. 52C, pp. 60–64.

    Google Scholar 

  94. Jensen, J.A., J. Exp. Med., 1969, vol. 130, pp. 217–241.

    PubMed  CAS  Google Scholar 

  95. Hensens, O.D., Borris, R.P., Koupal, L.R., Caldwell, C.G., Currie, S.A., Haidri, A.A., Homnick, C.F., Honeycutt, S.S., Lindenmayer, S.M., Schwartz, C.D., Weissberger, B.A., Woodruff, H.B., Zink, D.L., Zitano, L., Fieldhouse, J.M., Rollins, T., Springer, M.S., and Springer, J.P., J. Antibiot., 1991, vol. 44, pp. 249–254.

    PubMed  CAS  Google Scholar 

  96. Tsuji, R.F., Uramoto, M., Koshino, H., Tsuji, N.M., Magae, J., Nagai, K., and Yamasaki, M., Boisci. Biotechnol. Biochem., 1992, vol. 56, pp. 1686–1689.

    Article  CAS  Google Scholar 

  97. Kourounakis, L., Nelson, R.A., Jr., and Kapusta, M.A., Arthritis. Rheum., 1973, vol. 16, pp. 71–76.

    PubMed  CAS  Google Scholar 

  98. Jungi, T.W. and McGregor, D.D., Infect. Immun., 1979, vol. 23, pp. 633–643.

    PubMed  CAS  Google Scholar 

  99. Chen, T. and Rael, E.D., Int. J. Biochem. Cell Biol., 1997, vol. 29, pp. 789–799.

    PubMed  CAS  Google Scholar 

  100. Etievant, M., Leluc, B., and David, B., Agents Actions, 1988, vol. 24, pp. 137–144.

    PubMed  CAS  Google Scholar 

  101. Laclette, J.P., Shoemaker, C.B., Richter, D., Arcos, L., Pante, N., Cohen, C., Bing, D., and Nicholson Weller, A., J. Immunol., 1992, vol. 148, pp. 124–128.

    PubMed  CAS  Google Scholar 

  102. Cimanga, K., De Bruyne, T., Lasure, A., van Poel, B., Pieters, L., van den Berghe, D., Vlietinck, A., Kambu, K., and Tona, L., J. Nat. Prod., 1995, vol. 58, pp. 372–378.

    PubMed  CAS  Google Scholar 

  103. Ecker, E.E. and Gross, P., J. Infect. Dis., 1929, vol. 44, pp. 250–253.

    CAS  Google Scholar 

  104. Jaques, L.B., Pharmacol. Rev., 1979, vol. 31, pp. 99–166.

    PubMed  CAS  Google Scholar 

  105. Buckel, P., Trends Pharmacol. Sci., 1996, vol. 17, pp. 450–456.

    PubMed  CAS  Google Scholar 

  106. Grindley, J.N. and Ogden, J.E., Scrip. Mag., 1995, vol. 11, pp. 53–56.

    Google Scholar 

  107. Verlinde, C.L.M. and Hol, W.G.J., Structure, 1994, vol. 2, pp. 577–587.

    PubMed  CAS  Google Scholar 

  108. Hruby, V.J., Drug Discovery Today, 1997, vol. 2, pp. 165–167.

    Google Scholar 

  109. Kawai, M., Quincy, D.A., Lane, B., Mollison, K.W., Luly, J.R., and Carter, G.W., J. Med. Chem., 1991, vol. 34, pp. 2068–2071.

    PubMed  CAS  Google Scholar 

  110. Kawai, M., Quincy, D.A., Lane, B., Mollison, K.W., Or, Y.S., Luly, J.R., and Carter, G.W., J. Med. Chem., 1992, vol. 35, pp. 220–223.

    PubMed  CAS  Google Scholar 

  111. Or, Y.S., Clark, R.F., Lane, B., Mollison, K.W., Carter, G.W., and Luly, J.R., J. Med. Chem., 1992, vol. 35, pp. 402–406.

    PubMed  CAS  Google Scholar 

  112. Konteatis, Z.D., Siciliano, S.J., van Riper, G., Molineaux, C.J., Pandya, S., Fischer, P., Rosen, H., Mumford, R.A., and Springer, M.S., J. Immunol., 1994, vol. 153, pp. 4200–4205.

    PubMed  CAS  Google Scholar 

  113. Kretzschmar, T., Pohl, M., Casaretto, M., Przewosny, M., Bautsch, W., Klos, A., Saunders, D., and Kohl, J., Eur. J. Biochem., 1992, vol. 210, pp. 185–191.

    PubMed  CAS  Google Scholar 

  114. Sahu, A., Kay, B.K., and Lambris, J.D., J. Immunol., 1996, vol. 157, pp. 884–891.

    PubMed  CAS  Google Scholar 

  115. Boackle, R.J., Johnson, B.J., and Caughman, G.B., Nature, 1979, vol. 282, pp. 742–743.

    PubMed  CAS  Google Scholar 

  116. Lukas, T.J., Munoz, H., and Erickson, B.W., J. Immunol., 1981, vol. 127, pp. 2555–2560.

    PubMed  CAS  Google Scholar 

  117. Reid, K.B.M., Sim, R.B., and Faiers, A.P., Biochem. J., 1977, vol. 161, pp. 239–245.

    PubMed  CAS  Google Scholar 

  118. Kossorotow, A., Opitz, W., Etschenberg, E., and Hadding, U., Biochem. J., 1977, vol. 167, pp. 377–382.

    PubMed  CAS  Google Scholar 

  119. Lesavre, P., Gaillard, M.H., and Halbwachs-Mecarelli, L., Eur. J. Immunol., 1982, vol. 12, pp. 252–254.

    PubMed  CAS  Google Scholar 

  120. Fryer, J.P., Blondin, B., Stadler, C., Ivancic, D., Rattner, U., Kaplan, B., Kaufman, D., Abecassis, M., Stuart, F., and Anderson, B., Transplant. Proc., 1997, vol. 29, p. 883.

    PubMed  CAS  Google Scholar 

  121. Ogata, R.T. and Low, P.J, J. Immunol., 1997, vol. 158, pp. 3852–3860.

    PubMed  CAS  Google Scholar 

  122. Hong, K., Kinoshita, T., Miyazaki, W., Izawa, T., and Inoue, K., J. Immunol., 1979, vol. 122, pp. 2418–2423.

    PubMed  CAS  Google Scholar 

  123. Tanaka, M., Murase, N., Ye, Q., Miyazaki, W., Nomoto, M., Miyazawa, H., Manez, R., Toyama, Y., Demetris, A.J., Todo, S., and Starzl, T.E., Transplantation, 1996, vol. 62, pp. 681–688.

    PubMed  CAS  Google Scholar 

  124. Miyazaki, W., Izawa, T., Nakano, Y., Shinohara, M., Hing, K., Kinoshita, T., and Inoue E., Complement, 1984, vol. 1, pp. 134–146.

    PubMed  CAS  Google Scholar 

  125. Sindelar, R.D., Bradbury, B.J., Kaufman, T.S., Ip, S.H., Marsh, H.C., Jr., and Lee N, US Patent 5 506 247, 1996.

  126. Minta, J.O., Urowitz, M.B., Smythe, H.A., and Isenman, D.E., Clin. Exp. Immunol., 1983, vol. 53, pp. 555–561.

    PubMed  CAS  Google Scholar 

  127. Kashyap, A., Sehgal, V.N., Sahu, A., and Saha, K., Int. J. Immunopharmacol., 1992, vol. 14, pp. 269–273.

    PubMed  CAS  Google Scholar 

  128. Saez, C., Thielens, N.M., Bjes, E.S., and Esser, A.F., Biochemistry, 1999, vol. 38, pp. 6807–6816.

    PubMed  CAS  Google Scholar 

  129. Conrow, R.B., Bauman, N., Brockman, J.A., and Bernstein, S., J. Med. Chem., 1980, vol. 23, pp. 240–242.

    PubMed  CAS  Google Scholar 

  130. Harrity, T.W. and Goldlust, M.B., Biochem. Pharmacol., 1974, vol. 23, pp. 3107–3120.

    PubMed  CAS  Google Scholar 

  131. Glovsky, M.M., Becker, E.L., and Halbrook, N.J., J. Immunol., 1968, vol. 100, pp. 979–990.

    PubMed  CAS  Google Scholar 

  132. Oshuci, Y., Matsuno, T., and Takacaki, Y., Chem. Pharm. Bull. (Tokyo), 1977, vol. 25, pp. 1202–1208.

    Google Scholar 

  133. DiPerri, T., Forconi, S., Auteri, A., Vittor, A., Pasini, F.L., and Guercini, F., Minerva Nefrol., 1974, vol. 21, pp. 147–155.

    CAS  Google Scholar 

  134. Assefa, H., Nimrod, A., Walker, L., and Sindelar, R., Bioorg. Med. Chem. Lett., 1999, vol. 9, pp. 1889–1894.

    PubMed  CAS  Google Scholar 

  135. Master, H.E., Khan, S.I., and Poojari, K.A., Bioorg. Med. Chem. Lett., 2003, vol. 13, pp. 1249–1251.

    PubMed  CAS  Google Scholar 

  136. Bureeva, S., Andia-Pravdivy, Y., Petrov, G., Igumnov, M., Romanov, S., Kolesnikova, E., Kaplun, A., and Kozlov, L., Bioorg. Med. Chem., 2005, vol. 13, pp. 1045–1052.

    PubMed  CAS  Google Scholar 

  137. Kaplun, A.P., Andia-Pravdivy, Yu.E., Bureeva, S.V., Kozlov, L.V., and Shvets, V.I., RF Patent 2243233, Byull. Izobret., 2004, no. 36.

  138. Aoyama, T., Ino, Y., Ozeki, M., Oda, M., Sato, T., Koshiyama, Y., Suzuki, S., and Fujita, M., Jpn. J. Pharmacol., 1984, vol. 35, pp. 203–227.

    PubMed  CAS  Google Scholar 

  139. Kreil, E., Montalescot, G., Greene, E., Fitzgibbon, C., Robinson, D., Chenoweth, D., and Zapol, W.M., J. Appl. Physiol., 1989, vol. 67, pp. 1463–1471.

    PubMed  CAS  Google Scholar 

  140. Issekutz, A.C., Roland, D.M., and Patrick, R.A., Int. J. Immunopharmacol., 1990, vol. 12, pp. 1–9.

    PubMed  CAS  Google Scholar 

  141. Fujii, S. and Hitomi, Y., Biochim. Biophys. Acta, 1981, vol. 661, pp. 342–345.

    PubMed  CAS  Google Scholar 

  142. Kilpatrick, J.M., New Therapeutic Targets Based on Control of Complement System, Boston, MA, June 9–11, 1997.

  143. Subasinghe, N.L., An F., Illig, C.R., Jonathan, R.M., Klein, S., Khalil, E., Soll, R.M., Bone, R.F., Spurlino, J.C., DesJarlais, R.L., Crysler, C.S., Cummings, M.D., Morris, P.E., Jr., Kilpatrick, J.M., and Sudhakara Babu, Y., Bioorg. Med. Chem. Lett., 2004, vol. 14, pp. 3043–3047.

    PubMed  CAS  Google Scholar 

  144. Ovcharov, R., Mikhailova, S., and Gencheva, G., Eksp. Med. Morfol., 1976, vol. 15, pp. 141–145.

    PubMed  CAS  Google Scholar 

  145. Kam, C.M., Oglesby, T.J., Pangburn, M.K., Volanakis, J.E., and Powers, J.S., J. Immunol., 1992, vol. 149, pp. 163–168.

    PubMed  CAS  Google Scholar 

  146. Doherty, N.S., Int. J. Immunopharmacol., 1982, vol. 4, pp. 67–72.

    PubMed  CAS  Google Scholar 

  147. du Toit, H.J., Macfarlane, C.M., Taljaard, J.J., King, J.B., and Cooper, R.C., S. Afr. Med. J., 1987, vol. 71, pp. 279–282.

    PubMed  Google Scholar 

  148. Terasawa, M., Goto, K., and Maruyama, Y., Nippon Yakurigaku Zasshi, 1982, vol. 80, pp. 417–427.

    PubMed  CAS  Google Scholar 

  149. Mao, T.S.S., Moval, J.J., Pellerin, P., and Plescia, O.J., Can. J. Biochem., 1969, vol. 47, pp. 547–552.

    PubMed  CAS  Google Scholar 

  150. Allan, R., Rodrick, M., Knobel, H.R., and Isliker, H., Int. Arch. Appl. Immunol., 1979, vol. 58, pp. 140–148.

    CAS  Google Scholar 

  151. Kilgore, K.S., Homeister, J.W., Satoh, P.S., and Lucchesi, B.R., Am. J. Physiol., 1994, vol. 266, pp. 28–35.

    Google Scholar 

  152. Tsibulkin, A.P. and Raizman, S.M., Farmakol. Toksikol., 1981, vol. 44, pp. 316–319.

    CAS  Google Scholar 

  153. Nakagami, T., Toyomura, K., Kinoshita, T., and Morisawa, S., Biochim. Biophys. Acta, 1993, vol. 1158, pp. 189–193.

    PubMed  CAS  Google Scholar 

  154. Harper, B.L., Fine, D.P., Guckian, J.C., and Cavallo, T., Immunology, 1981, vol. 42, pp. 61–66.

    PubMed  CAS  Google Scholar 

  155. Aschar, S.S. and Kammeuer, A., Mol. Immunol., 1979, vol. 16, pp. 117–121.

    Google Scholar 

  156. Peake, P.W., Pussell, B.A., Martyn, P., Timmermans, V., and Charlesworth, J., A, Int. J. Immunopharmacol., 1991, vol. 13, pp. 853–857.

    PubMed  CAS  Google Scholar 

  157. Sim, E., Gill, E.W., and Sim, R.B., Lancet, 1984, vol. 2, pp. 422–424.

    PubMed  CAS  Google Scholar 

  158. Sim, E., Stanley, L., Gill, E.W., and Jones, A., Biochem. J., 1988, vol. 251, pp. 323–326.

    PubMed  CAS  Google Scholar 

  159. Andersson, M., Hanson, A., Englund, G., and Dahlbáck, B., Sweden Eur. J. Clin. Pharmacol., 1991, vol. 40, pp. 261–265.

    CAS  Google Scholar 

  160. Sim, E., Dodds, A.W., and Goldin, A., Biochem. J., 1989, vol. 259, pp. 415–419.

    PubMed  CAS  Google Scholar 

  161. Cole, L.B., Chu, N.M., Kilpatrick, J.M., Volanakis, J.E., Narayana, S.V.L., and Babu, Y.S., Acta. Crystallogr. D, 1997, vol. 53, pp. 143–150.

    PubMed  CAS  Google Scholar 

  162. Fearon, D.T., Austen, K.F., and Ruddy, S., J. Exp. Med., 1974, vol. 139, pp. 355–366.

    PubMed  CAS  Google Scholar 

  163. Gancevici, G.G., Roum. Arch. Microbiol. Immunol., 1993, vol. 52, pp. 293–303.

    PubMed  CAS  Google Scholar 

  164. Asghar, S.S., Siddiqui, A.H., van der Goot, H., and Timmerman, H., Mol. Immunol., 1986, vol. 23, pp. 459–465.

    PubMed  CAS  Google Scholar 

  165. Huang, Y., De Bruyne, T., Apers, S., Ma, Y., Claeys, M., van den Berghe, D., Pieters, L., and Vlietinck, A., J. Nat. Prod., 1998, vol. 61, pp. 757–761.

    PubMed  CAS  Google Scholar 

  166. Rosse, W.F., Logue, G.L., Silberman, H.R., and Frank, M.M., Trans. Assoc. Am. Physicians, 1976, vol. 89, pp. 122–132.

    PubMed  CAS  Google Scholar 

  167. Gadek, J., Hosea, S.W., Gelfand, J.A., and Frank, M.M., J. Clin. Invest., 1979, vol. 64, pp. 280–286.

    Article  PubMed  CAS  Google Scholar 

  168. Gerard, N. and Gerard, N.P., Annu. Rev. Immunol., 1994, vol. 12, pp. 775–808.

    PubMed  CAS  Google Scholar 

  169. Hartmann, K., Henz, B.M., Kruger-Krasagakes, S., Kohl, J., Burger, R., Guhl, S., Haase, I., Lippert, U., and Zuberbier, T., Blood, 1997, vol. 89, pp. 2863–2870.

    PubMed  CAS  Google Scholar 

  170. Fernandez, H.N. and Hugh, O.A, J. Biol. Chem., 1978, vol. 253, pp. 6955–6964.

    PubMed  CAS  Google Scholar 

  171. Gerard, N.P. and Gerard N., Nature, 1991, vol. 349, pp. 614–617.

    PubMed  CAS  Google Scholar 

  172. Boulay, F., Mery, L., Tardif, M., Brouchon, L., and Vignais, P., Biochemistry, 1991, vol. 30, pp. 2993–2999.

    PubMed  CAS  Google Scholar 

  173. Mollison, K.W., Krause, R.A., Fey, T.A., Miller, L., Wiedeman, P.E., Kawai, M., Lane, B., Luly, J.R., and Carter, G.W., FASEB J., 1992, vol. 6, p. 2058.

    Google Scholar 

  174. Zhang, X., Boyar, W., Galakatos, N., and Gonnella, N.C., Protein Sci., 1997, vol. 6, pp. 65–72.

    PubMed  CAS  Google Scholar 

  175. Sahu, A., Morikis, D., Soulika, A.M., Spruce, L., Moore, W.T., and Lambris, J.D., Mol. Immunol., 1998, vol. 35, p. 371.

    Google Scholar 

  176. Fiane, A.E., Mollnes, T.E., Videm, V., Hovig, T., Hogasen, K., Mellbye, O.J., Spruce, L., Moore, W.T., Sahu, A., and Lambris, J.D., Transplant. Proc., 1999, vol. 31, pp. 934–935.

    PubMed  CAS  Google Scholar 

  177. Fiane, A.E., Mollnes, T.E., Videm, V., Hovig, T., Hogasen, K., Mellbye, O.J., Spruce, L., Moore, W.T., Sahu, A., and Lambris, J.D., Xenotransplantation, 1999, vol. 6, pp. 52–65.

    PubMed  CAS  Google Scholar 

  178. Nilsson, B., Larsson, R., Hong, J., Elgue, G., Ekdahl, K.N., Sahu, A., and Lambris, J.D., Blood, 1998, vol. 92, pp. 1661–1667.

    PubMed  CAS  Google Scholar 

  179. Morikis, D., Assa-Munt, N., Sahu, A., and Lambris, J.D., Protein Sci., 1998, vol. 7, pp. 619–627.

    Article  PubMed  CAS  Google Scholar 

  180. Inagi, R., Miyata, T., Maeda, K., Sugiyama, S., Miyama, A., and Nakashima, I., Immunol. Lett., 1991, vol. 27, pp. 49–52.

    PubMed  CAS  Google Scholar 

  181. Araida, T., Frey, C.F., Ruebner, B., Carlson, J., and King, J., Pancreas, 1995, vol. 11, pp. 132–140.

    PubMed  CAS  Google Scholar 

  182. Yanamoto, H., Kikuchi, H., Sato, M., Shimizu, Y., Yoneda, S., Okamoto, S., and Findlay, J.M., Neurosurgery, 1992, vol. 30, pp. 358–363.

    PubMed  CAS  Google Scholar 

  183. Narayana, S.V., Carson, M., Kabbani, O., Kilpatrick, J.M., Moore, D., Chen, X., Bugg, C.E., Volanakis, J.E., and DeLucas, L.J., J. Mol. Biol., 1994, vol. 235, pp. 695–708.

    PubMed  CAS  Google Scholar 

  184. Kim, S., Narayana, S.V.L., and Volanakis, J.E., J. Biol. Chem., 1995, vol. 270, pp. 24 399–24 405.

    CAS  Google Scholar 

  185. Jing, H., Babu, Y.S., Moore, D., Kilpatrick, J.M., Liu, X.Y., Volanakis, J.E., and Narayana, S.V., J. Mol. Biol., 1998, vol. 282, pp. 1061–1081.

    PubMed  CAS  Google Scholar 

  186. Szalai, A.J., Digerness, S.B., Agrawal, A., Kearney, J.F., Bucy, R.P., Niwas, S., Kilpatrick, J.M., Babu, Y.S., and Volanakis, J.E., J. Immunol., 2000, vol. 164, pp. 463–468.

    PubMed  CAS  Google Scholar 

  187. Hong, K., Kinoshita, T., Kitajima, H., and Inoue, K., J. Immunol., 1980, vol. 127, pp. 104–108.

    Google Scholar 

  188. Konno, S. and Tsurufuji, S., Br. J. Pharmacol., 1983, vol. 80, pp. 269–277.

    PubMed  CAS  Google Scholar 

  189. Iida, H., Izumino, K., Asaka, M., Takata, M., Mizumura, Y., and Sasayama, S., Clin. Exp. Immunol., 1987, vol. 67, pp. 130–134.

    PubMed  CAS  Google Scholar 

  190. Yamada, H., Kudoh, I., Nishizawa, H., Kaneko, K., Miyazaki, H., Ohara, M., and Okumura, F., Acta Anaesthesiol. Scand., 1997, vol. 41, pp. 713–718.

    Article  PubMed  CAS  Google Scholar 

  191. Blum, M.G., Collins, B.J., Chang, A.C., Zhang, J.P., Knaus, S.A., and Pierson, R.N., Xenotransplantation, 1998, vol. 5, pp. 35–43.

    PubMed  CAS  Google Scholar 

  192. Kaufman, T.S., Srivastava, R.P., Sindelar, R.D., Scesney, S.M., and Marsh, H.C., Jr., Bioorg. Med. Chem. Lett., 1995, vol. 5, pp. 501–506.

    CAS  Google Scholar 

  193. Kaufman, T.S., Srivastava, R.P., Sindelar, R.D., Scesney, S.M., and Marsh, H.C., Jr., J. Med. Chem., 1995, vol. 38, pp. 1437–1445.

    PubMed  CAS  Google Scholar 

  194. Levine, R.P. and Dodds, A.W., Curr. Top. Microbiol. Immunol., 1990, vol. 153, pp. 73–82.

    PubMed  CAS  Google Scholar 

  195. Isenman, D.E. and Young, J.R., J. Immunol., 1984, vol. 132, pp. 3019–3027.

    PubMed  CAS  Google Scholar 

  196. Law, S.K.A., Dodds, A.W., and Porter, R.R., EMBO J., 1984, vol. 3, pp. 1819–1823.

    PubMed  CAS  Google Scholar 

  197. Sahu, A. and Pangburn, M.K., Mol. Immunol., 1995, vol. 32, pp. 711–716.

    PubMed  CAS  Google Scholar 

  198. Sahu, A. and Pangburn, M.K., Biochem. Pharmacol., 1996, vol. 51, pp. 797–804.

    PubMed  CAS  Google Scholar 

  199. Sahu, A., Kozel, T.R., and Pangburn, M.K., Biochem. J., 1994, vol. 302, pp. 429–436.

    PubMed  CAS  Google Scholar 

  200. Sahu, A., Rawal, N., and Pangburn, M.K., Biochem. Pharmacol., 1999, vol. 57, pp. 1439–1446.

    PubMed  CAS  Google Scholar 

  201. Kozlov, L.V., Rostovtseva, L.I., Lomaka, T.S., and Sutovskaya, N.S., Bioorg. Khim., 1985, vol. 11, pp. 762–768.

    PubMed  CAS  Google Scholar 

  202. Kozlov, L.V., Rostovtseva, L.I., Lomaka, T.S., Sutovskaya, N.S., Sorokina, I.B., and Barkova, T.I., Bioorg. Khim., 1985, vol. 11, pp. 1510–1518.

    PubMed  CAS  Google Scholar 

  203. Kozlov, L.V. and Lebedeva, T.V., Bioorg. Khim., 1998, vol. 24, pp. 350–355.

    PubMed  CAS  Google Scholar 

  204. Kozlov, L.V., Lakhtin, V.M., Skorokhodova, T.G., Batalova, T.N., Shoibonov, V.V., D’yakov, V.L., Guzova, V.A., and Matveevskaya, N.S., Bioorg. Khim., 2000, vol. 26, pp. 817–824; Rus. J. Bioorg. Chem., 2000, vol. 26, pp. 734–740.

    PubMed  CAS  Google Scholar 

  205. Kozlov, L.V., Lakhtin, V.M., Batalova, T.N., Guzova, V.A., D’yakov, V.L., and Romanov, S.V., Vestnik Mosk. Gos. Univ., Ser. 2, Khimiya, vol. 41, no. 6, Suppl., pp. 88–90.

  206. Schiller, C., Spittler, A., Willheim, M., Szépfalusi, Z., Agis, H., Köller, M., Peterlik, M., and Boltz Nitulescu, G., Immunology, 1994, vol. 81, pp. 598–604.

    PubMed  CAS  Google Scholar 

  207. Eisen, V. and Loveday, N., Br. J. Pharmacol., 1973, vol. 49, pp. 678–687.

    PubMed  CAS  Google Scholar 

  208. Fong, J.S.C. and Good, R.A., Clin. Exp. Immunol., 1972, vol. 10, pp. 127–138.

    PubMed  CAS  Google Scholar 

  209. Rommel, F.A. and Stolfi, R., Immunology, 1968, vol. 15, pp. 469–479.

    PubMed  CAS  Google Scholar 

  210. Stolm, R.L., J. Immunol., 1970, vol. 104, pp. 1212–1219.

    Google Scholar 

  211. Lachmann, P.J. and Elias, D.E., in Symposia on Biological Activities of Complement, Ingram, D.G., Ed., Basel: Kayser, 1971, pp. 202–214.

    Google Scholar 

  212. Wetsel, R.A. and Colten, H.R., in Kluwer Academic, Norwell, 1990, pp. 401–429.

  213. Fischer, M.B., Prodeus, A.P., Nicholson-Weller, A., Ma, M.H., Murrow, J., Reid, R.R., Warren, H.B., Lage, A.L., Moore, F.D.J., Rosen, F.S., and Carroll, M.C., J. Immunol., 1997, vol. 159, pp. 976–982.

    PubMed  CAS  Google Scholar 

  214. Kozlov, L.V. and Guzova, V.A., Opredelenie komplementaktiviruyushchei aktivnosti preparatov dlya vnutrivennogo vvedeniya. Metodicheskie rekomendatsii no. 98/87 (Determination of Complement-activating Activity of Preparations for Intravenous Administration: Methodological Advices no. 98/87), Moscow: Minzdrav RF, 1998.

    Google Scholar 

  215. Kozlov, L.V., Zhdanov, R.I., Guzova, V.A., Podobed, O.V., Sviridov, Yu.V., Bogdanenko, E.V., Shvets, V.I., Dyabina, O.S., and Ermakov, A.S., Cytobios, 2001, vol. 106, pp. 67–74.

    PubMed  CAS  Google Scholar 

  216. Chonn, A., Cullis, P.R., and Devine, D.V., J. Immunol., 1991, vol. 146, pp. 4234–4241.

    PubMed  CAS  Google Scholar 

  217. Kozlov, L.V., Sizoi, M.L., Zinchenko, A.A., and Levkovskii, A.V., Biokhimiya (Moscow), 1986, vol. 51, pp. 707–718.

    CAS  Google Scholar 

  218. Kozlov, L.V., D’yakov, V.L., Batalova, T.N., Guzova, V.A., and Lysakova, S.V., RF Patent 2 144 676, Byull. Izobret., 2000, no. 2.

  219. Kozlov, L.V., Belkin, Z.P., Bichucher, A.M., Batalova, T.N., and D’yakov, V.L., Biomed. Khim., 2003, vol. 49, pp. 284–289.

    PubMed  CAS  Google Scholar 

  220. Burdelev, O.O., Kaplun, A.P., Kozlov, L.V., Lysakova, S.V., D’yakov, V.L., and Shvets, V.I., Bioorg. Khim., 2003, vol. 29, pp. 159–162; Rus. J. Bioorg. Chem., 2003, vol. 29, pp. 139–142.

    PubMed  CAS  Google Scholar 

  221. Kozlov, L.V., Belkin, Z.P., Andina, S.S., and Kaplun, A.P., RF Patent 2 202 836, Byull. Izobret., 2003, no. 11.

  222. Kozlov, L.V., Romanov, S.V., Batalova, T.N., Lakhtin, V.M., Guzova, V.A., and D’yakov, V.L., RF Patent 2195664, Byull. Izobret., 2002, no. 36.

  223. Osipov, A.V., Mordvintsev, D.Yu., Starkov, V.G., Galebskaya, L.V., Ryumina, E.V., Bel’tyukov, P.P., Kozlov, L.V., Romanov, S.V., Doljansky, Y., Tsetlin, V.I., and Utkin, Yu.N., Toxicon, 2005, vol. 46, pp. 394–403.

    PubMed  CAS  Google Scholar 

  224. Kozlov, L.V., Kolesnikova, E.A., D’yakov, V.L., and Lakhtin, V.M., RF Patent 2 235 325, Byull. Izobret., 2004, no. 24.

  225. Carroll, M.C. and Fischer, M.B., Curr. Opin. Immunol., 1997, vol. 9, pp. 64–69.

    PubMed  CAS  Google Scholar 

  226. Kozlov, L.V., Skorokhodova, T.G., Batalova, T.N., Lakhtin, V.M., Matveevskaya, N.S., Guzova, V.A., and D’yakov, V.L., RF Patent 2 149 406, Byull. Izobret., 2000, no. 14.

  227. Kozlov, L.V., Skorokhodova, T.G., Batalova, T.N., Lakhtin, V.M., Matveevskaya, N.S., Guzova, V.A., and D’yakov, V.L., RF Patent 2 162 601, Byull. Izobret., 2001, no. 3.

  228. Kozlov, L.V., Skorokhodova, T.G., Batalova, T.N., Lakhtin, V.M., Matveevskaya, N.S., and Shoibonov, B.B., RF Patent 2 162 602, Byull. Izobret., 2001, no. 3.

  229. Kozlov, L.V. and Lebedeva, T.V., Bioorg. Khim., 1998, vol. 24, pp. 350–355.

    PubMed  CAS  Google Scholar 

  230. Kozlov, L.V., Romanov, S.V., Batalova, T.N., Lakhtin, V.M., Guzova, V.A., and D’yakov, V.L., RF Patent 2195664, Byull. Izobret., 2002, no. 36.

  231. Kozlov, L.V., Romanov, S.V., Batalova, T.N., Lakhtin, V.M., Guzova, V.A., and D’yakov, V.L., RF Patent 2195665, Byull. Izobret., 2002, no. 36.

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  1. Gabrichevskii Research Institute of Epidemiology and Microbiology, ul. Admirala Makarova 10, Moscow, 125212, Russia

    L. V. Kozlov

  2. Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 117851, Russia

    O. O. Burdelev, S. V. Bureeva & A. P. Kaplun

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Original Russian Text © L.V. Kozlov, O.O. Burdelev, S.V. Bureeva, A.P. Kaplun, 2007, published in Bioorganicheskaya Khimiya, 2007, Vol. 33, No. 5, pp. 485–510.

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Kozlov, L.V., Burdelev, O.O., Bureeva, S.V. et al. Artificial inhibition of the complement system. Russ J Bioorg Chem 33, 449–473 (2007). https://doi.org/10.1134/S1068162007050020

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