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Cytotoxic derivatives of (22R,23R)-dihydroxystigmastane

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Abstract

(22R,23R)-22,23-dihydroxystigmast-4-en-3-one, (22R,23R)-22,23-dihydroxystigmast-4-en-3,6-dione, (22R,23R)-3β,5α,6β,22,23-pentahydroxystigmastane, (22R,23R)-5α,6α-oxido-3β,22,23-trihydroxystigmastane, (22R,23R)-5β,6β-oxido-3β,22,23-trihydroxystigmastane, and (22R,23R)-3β,6β,22,23-tetrahydroxystigmast-4-ene were synthesized. Their cytotoxicities were comparatively studied using the MCF-7 line of carcinoma cells of human mammary gland and cells of human hepatoma of the Hep G2 line.

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Abbreviations

CPBA:

m-chlorobenzoic acid

FCS:

fetal calf serum

MTT:

3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide

NBA:

N-bromacetamide

PBS:

phosphate-buffered saline

TosOH:

p-toluenesulfonic acid

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Authors and Affiliations

  1. Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya ul. 10, Moscow, 119832, Russia

    F. V. Drozdov, A. P. Mekhtiev, G. E. Morozevich & A. Yu. Misharin

  2. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 117984, Russia

    V. P. Timofeev

Authors
  1. F. V. Drozdov
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  2. A. P. Mekhtiev
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  3. G. E. Morozevich
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  4. V. P. Timofeev
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  5. A. Yu. Misharin
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Corresponding author

Correspondence to A. Yu. Misharin.

Additional information

Original Russian Text © F.V. Drozdov, A.P. Mekhtiev, G.E. Morozevich, V.P. Timofeev, A.Yu. Misharin, 2007, published in Bioorganicheskaya Khimiya, 2007, Vol. 33, No. 3, pp. 349–356.

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Drozdov, F.V., Mekhtiev, A.P., Morozevich, G.E. et al. Cytotoxic derivatives of (22R,23R)-dihydroxystigmastane. Russ J Bioorg Chem 33, 326–333 (2007). https://doi.org/10.1134/S1068162007030090

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  • DOI: https://doi.org/10.1134/S1068162007030090

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