Abstract
Data on involvement of nitric oxide in apoptosis are contradictory. The balance between anti- and proapoptotic activities of nitric oxide depends on many factors, including its concentration in a tissue and interactions with other regulators of apoptosis. This paper describes the results of a series of experiments on the effect of nitric oxide donors and inhibitors as well as dNOS1 and dNOS4 transgenes on the apoptosis on drosophila Lobe RSV mutant strain and wild-type strain Oregon R. It has been shown that a high nitric oxide content in cells is able to inhibit antiapoptotic effect of HSP70 and stimulate apoptosis, possibly, via the grim-mediated apoptotic pathway. Moreover, long-term action of a high nitric oxide concentration during the entire development more efficiently stimulates the proapoptotic genes as compared with short-term action of this agent.
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Original Russian Text © L.B. Djansugurova, 2011, published in Ontogenez, 2011, Vol. 42, No. 6, p. 426–439.
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Djansugurova, L.B. Effect of nitric oxide on expression of apoptotic genes and HSP70 in drosophila. Russ J Dev Biol 42, 376–388 (2011). https://doi.org/10.1134/S1062360411060026
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DOI: https://doi.org/10.1134/S1062360411060026