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Catechol-oxide-methyltransferase (COMT rs4680:G>A) gene polymorphism does not affect analgesics’ demand after elective hip replacement

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Abstract

Pain in patients with hip osteoarthritis appears long before surgery, and requires effective management as it affects patient comfort and daily activities. Therefore, the search for factors influencing response rate to analgesics is mandatory. In recent years, increasing attention has been paid to genetic factors underlying pain threshold and treatment efficacy. Polymorphic gene of catechol-oxide-methyltransferase (COMT) is a candidate gene associated with pain pathology and treatment response. The aim of the study was to evaluate association between the COMT rs4680:G>A polymorphism and demand for analgesics in patients subjected to elective hip replacement. The study included 196 patients after hip replacement surgery. Opioid demand was recorded and analgesic efficacy was scored using a four-level verbal pain intensity scale. COMT rs4680:G>A polymorphism was analysed by PCR-RFLP method. The studied COMT genotypes did not influence opioid administration in the studied patients from the day of surgery till day 6 afterwards. The distribution of the COMT rs4680:G>A in the studied subjects was as follows: GA—52.04%, AA—23.98% and GG—23.98%. It can be concluded that the COMT rs4680:G>A polymorphism is not associated with opioid demand in patients after elective hip replacement.

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Authors and Affiliations

  1. Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, 70-111, Szczecin, Poland

    M. Białecka, A. Machoy-Mokrzyńska, M. Kurzawski & M. Droździk

  2. Department of Orthopaedics, Traumatology and Orthopaedic Oncology, Pomeranian Medical University, 71-252, Szczecin, Poland

    A. Jurewicz & A. Bohatyrewicz

  3. Department of Biological Basis of Physical Culture, Institute of Physical Culture and Health Promotion, Szczecin University, 71-065, Szczecin, Poland

    P. Cięszczyk

  4. Department of Human Functional Anatomy and Biometry, Institute of Physical Culture and Health Promotion, Szczecin University, 71-065, Szczecin, Poland

    K. Leźnicka

  5. Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111, Szczecin, Poland

    V. Dziedziejko & K. Safranow

Authors
  1. M. Białecka
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  2. A. Jurewicz
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  3. P. Cięszczyk
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  4. A. Machoy-Mokrzyńska
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  6. K. Leźnicka
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  7. V. Dziedziejko
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  8. K. Safranow
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  9. M. Droździk
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  10. A. Bohatyrewicz
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Correspondence to K. Leźnicka.

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Białecka, M., Jurewicz, A., Cięszczyk, P. et al. Catechol-oxide-methyltransferase (COMT rs4680:G>A) gene polymorphism does not affect analgesics’ demand after elective hip replacement. Russ J Genet 52, 539–542 (2016). https://doi.org/10.1134/S1022795416030042

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  • DOI: https://doi.org/10.1134/S1022795416030042

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