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Effect of additional disease (Comorbidity) on association of allergic rhinitis with KCNE4 gene rs12621643 variant

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Abstract

Analysis of association of allergic rhinitis with the KCNE4 gene rs12621643 variant was conducted in Russian residents of West Siberia (taking into account comorbidity with bronchial asthma). It was found that, among individuals without bronchial asthma, the frequencies of the KCNE4*G allele and KCNE4*G/G genotype are significantly higher in patients with rhinitis compared to individuals without it. At the same time, no association of rs12621643 with rhinitis was detected in the group of individuals with bronchial asthma. The data obtained indicate the association of the KCNE4 gene variability with allergic rhinitis, although the effect of this gene relative to the development of the disease can be leveled against a background of the manifestation of another atopic disease.

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References

  1. Puzyrev, V.P., Phenome-Genome Relations and the Pathogenetics of Multifactorial Diseases, Vestn. Ross. Akad. Med. Nauk, 2011, no. 9, pp. 17–27.

    Google Scholar 

  2. Freidin, M.B. and Puzyrev, V.P., Syntropic Genes of Allergic Diseases, Russ. J. Genet., 2010, vol. 46, no. 2, pp. 224–229.

    Article  CAS  Google Scholar 

  3. Feinstein, A.R., The Pre-Therapeutic Classification of Co-Morbidity in Chronic Disease, J. Chron. Dis., 1970, vol. 23, pp. 455–468.

    Article  Google Scholar 

  4. Freidin, M.B. and Puzyrev, V.P., Genome Bases of Susceptibility to Atopic Diseases, Mol. Med., 2007, no. 3, pp. 26–35.

    Google Scholar 

  5. Palmer, C.N.A., Irvine, A.D., Terron-Kwiatkowski, A., et al., Common Loss-of-Function Variants of the Epidermal Barrier Protein Filaggrin Are a Major Predisposing Factor for Atopic Dermatitis, Nat. Genet., 2006, vol. 38, pp. 441–446.

    Article  PubMed  CAS  Google Scholar 

  6. Baurecht, H., Irvine, A.D., Novak, N., et al., Toward a Major Risk Factor for Atopic Eczema: Meta-Analysis of Filaggrin Polymorphism Data, J. Allergy Clin. Immunol., 2007, vol. 120, pp. 1406–1412.

    Article  PubMed  CAS  Google Scholar 

  7. Freidin, M.B., Bragina, E.Yu., Fedorova, O.S., et al., Genome-Wide Association Study of Allergic Diseases in Russians from West Siberia, Mol. Biol. (Moscow), 2011, vol. 45, no. 3, pp. 421–429.

    Article  CAS  Google Scholar 

  8. Solé, L. and Felipe, A., Does a Physiological Role for KCNE Subunits Exist in the Immune System, Commun. Integr. Biol., 2010, vol. 3, pp. 166–168.

    Article  PubMed  Google Scholar 

  9. Treviño, L.R., Yang, W., French, D., et al., Germline Genomic Variants Associated with Childhood Acute Lymphoblastic Leukemia, Nat. Genet., 2009, vol. 41, pp. 1001–1005.

    Article  PubMed  Google Scholar 

  10. Manderfield, L.J., Daniels, M.A., Vanoye, C.G., and George, A.L., Jr., KCNE4 Domains Required for Inhibition of KCNQ1, J. Physiol., 2009, vol. 587, pp. 303–314.

    Article  PubMed  CAS  Google Scholar 

  11. González, J.R., Armengol, L., Solé, X., et al., SNPassoc: An R Package to Perform Whole Genome Association Studies, Bioinformatics, 2007, vol. 1, pp. 644–645.

    Google Scholar 

  12. Bryborn, M., Halldén, C., Säll, T., and Cardell, L.O., CLC-A Novel Susceptibility Gene for Allergic Rhinitis? Allergy, 2010, vol. 65, pp. 220–228.

    Article  PubMed  CAS  Google Scholar 

  13. Miyake, Y., Tanaka, K., and Arakawa, M., Case-Control Study of IL13 Polymorphisms, Smoking, and Rhinoconjunctivitis in Japanese Women: The Kyushu Okinawa Maternal and Child Health Study, BMC Med. Genet., 2011, vol. 12, p. 143.

    Article  PubMed  CAS  Google Scholar 

  14. Tang, X.F., Tang, H.Y., Sun, L.D., et al., Genetic Variant rs4982958 at 14q11.2 Is Associated with Allergic Rhinitis in a Chinese Han Population Running Title: 14q11.2 Is a Susceptibility Locus for Allergic Rhinitis, J. Invest. Allergol. Clin. Immunol., 2012, vol. 22, pp. 55–62.

    CAS  Google Scholar 

  15. Yang, H.C., Chang, L.C., Liang, Y.J., et al., A Genome-Wide Homozygosity Association Study Identifies Runs of Homozygosity Associated with Rheumatoid Arthritis in the Human Major Histocompatibility Complex, PLoS One, 2012, vol. 7, p. e34840.

    Article  PubMed  CAS  Google Scholar 

  16. Kurotaki, N., Tasaki, S., Mishima, H., et al., Identification of Novel Schizophrenia Loci by Homozygosity Mapping Using DNA Microarray Analysis, PLoS One, 2011, vol. 6, p. e20589.

    Article  PubMed  CAS  Google Scholar 

  17. Sakai, H., Enzaka, J., Sakai-Oshita, M., et al., Involvement of K(+) Channels in the Augmented Nasal Venous Responsiveness to Nitric Oxide in Rat Model of Allergic Rhinitis, Microvasc. Res., 2011, vol. 81, pp. 129–134.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Research Institute of Medical Genetics, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, 634050, Russia

    M. B. Freidin, E. Yu. Bragina & V. P. Puzyrev

  2. Ministry of Health and Social Development of Russian Federation, Siberian State Medical University, Tomsk, 634050, Russia

    I. V. Saltykova, E. V. Deeva, L. M. Ogorodova & V. P. Puzyrev

Authors
  1. M. B. Freidin
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  2. E. Yu. Bragina
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  3. I. V. Saltykova
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  4. E. V. Deeva
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  5. L. M. Ogorodova
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  6. V. P. Puzyrev
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Corresponding author

Correspondence to M. B. Freidin.

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Original Russian Text © M.B. Freidin, E.Yu. Bragina, I.V. Saltykova, E.V. Deeva, L.M. Ogorodova, V.P. Puzyrev, 2013, published in Genetika, 2013, Vol. 49, No. 4, pp. 541–544.

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Freidin, M.B., Bragina, E.Y., Saltykova, I.V. et al. Effect of additional disease (Comorbidity) on association of allergic rhinitis with KCNE4 gene rs12621643 variant. Russ J Genet 49, 473–475 (2013). https://doi.org/10.1134/S1022795413040054

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  • DOI: https://doi.org/10.1134/S1022795413040054

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