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Polymorphic markers Ala455Val of the THBD gene and Arg353Gln of the F7 gene and genetic association with unfavorable outcomes of coronary atherosclerosis in patients with a history of acute ischemic heart disease

  • Human Genetics
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Abstract

The polymorphic markers Ala455Val of the THBD gene and Arg353Gln of the F7 gene were tested for association with the frequency of unfavorable outcomes in patients with a history of acute ischemic heart disease. The study involved 1145 patients hospitalized in cardiology clinics of Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol, and Rostov-on-Don because of acute ischemic heart disease. The patients were followed up for up to 62.5 months. None of the markers displayed a significant association with the time to an endpoint. The patients were then grouped by sex. In females, the frequency of unfavorable outcomes (fatal or nonfatal myocardial infarction and fatal or nonfatal stroke) was higher in carriers of allele Val of the Ala344Val polymorphic marker of the THBD gene and carriers of genotype Arg/Arg of the Arg353Gln polymorphic marker of the F7 gene, but the difference was not statistically significant. Such an increase in frequency was not observed in males. To study the combined effect of the polymorphic markers of the THBD and F7 genes, the course of ischemic heart disease was compared for two female subgroups. One included carriers of allele Val of the Ala344Val polymorphic marker of the THBD gene and genotype Arg/Arg of the Arg353Gln polymorphic marker of the F7 gene; the other subgroup included carriers of genotype Ala/Ala of the Ala455Val polymorphic marker of the THBD gene and allele Gln of the Arg353Gln polymorphic marker of the F7 gene. The frequency of unfavorable outcomes in the first subgroup was higher than in the second one. The time to an endpoin was 40.5 months (95% confidence interval (CI) 33.5–47.6) in the first subgroup and 51.6 months (95% CI 45.0–58.1) in the second subgroup (χ2 = 4.15, P = 0.042). The results made it possible to assume that the F7 and THBD genes play an important role in genetic predisposition to unfavorable outcomes in patients with a history of acute ischemic heart disease.

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Authors and Affiliations

  1. State Research Center GosNIIgenetika, Moscow, 117545, Russia

    A. A. Pushkov, K. A. Blagodatskikh, A. G. Nikitin, Yu. V. Agapkina, A. N. Brovkin, D. A. Chudakova & V. V. Nosikov

  2. Educational and Research Medical Center, Administration of the President of the Russian Federation, Moscow, 121359, Russia

    M. A. Evdokimova, O. Yu. Aseycheva, V. S. Osmolovskaya, L. O. Minushkina, B. A. Sidorenko & D. A. Zeteyshchikov

  3. Moscow Hospital no. 17, Moscow, 119620, Russia

    T. N. Baklanova & P. A. Talyzin

  4. Clinical Hospital no. 1, Administration of the President of the Russian Federation, Moscow, 197143, Russia

    O. P. Donetskaya

  5. Department of Emergency Care, Moscow State University of Medicine and Dentistry, Moscow, 127473, Russia

    S. N. Tereschenko, N. A. Dzhaiani & E. V. Akanova

  6. Sechenov Moscow Medical Academy, Moscow, 119991, Russia

    M. G. Glezer

  7. Department of Faculty Therapy, Kazan State Medical University, Kazan, 420012, Russia

    A. S. Galyavich & V. B. Zakirova

  8. Vagner Perm State Medical Academy, Perm, 614000, Russia

    N. A. Koziolova

  9. Stavropol State Medical Academy, Stavropol, 355014, Russia

    A. V. Yagoda & O. I. Boyeva

  10. 4th Department of Visceral Diseases, Rostov State Medical University, Rostov-on-Don, 344022, Russia

    E. V. Horolets & S. V. Shlyk

  11. Chelyabinsk State Medical Academy, Chelyabinsk, 454092, Russia

    E. G. Volkova, M. P. Margaryan & I. O. Guz

  12. Mechnikov St. Petersburg State Medical Academy, St. Petersburg, 195067, Russia

    V. O. Konstantinov

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  1. A. A. Pushkov
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  2. K. A. Blagodatskikh
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  6. D. A. Chudakova
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  7. M. A. Evdokimova
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  8. O. Yu. Aseycheva
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  9. V. S. Osmolovskaya
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  10. L. O. Minushkina
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  11. T. N. Baklanova
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  13. O. P. Donetskaya
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  14. S. N. Tereschenko
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  16. E. V. Akanova
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  17. M. G. Glezer
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  18. A. S. Galyavich
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  19. V. B. Zakirova
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  20. N. A. Koziolova
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  28. V. O. Konstantinov
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  29. B. A. Sidorenko
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  30. D. A. Zeteyshchikov
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  31. V. V. Nosikov
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Correspondence to A. A. Pushkov.

Additional information

Original Russian Text © A.A. Pushkov, K.A. Blagodatskikh, A.G. Nikitin, et al., 2011, published in Genetika, 2011, Vol. 47, No.10, pp. 1386–1392.

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Pushkov, A.A., Blagodatskikh, K.A., Nikitin, A.G. et al. Polymorphic markers Ala455Val of the THBD gene and Arg353Gln of the F7 gene and genetic association with unfavorable outcomes of coronary atherosclerosis in patients with a history of acute ischemic heart disease. Russ J Genet 47, 1234–1239 (2011). https://doi.org/10.1134/S1022795411100140

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