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Role of hormones in regulating sodium transporters in the kidney: Modulation of phosphorylation, traffic, and expression

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Abstract

The review focuses on the key sodium transporters involved in maintaining water–salt balance in the kidney. The topography of sodium transporters is discussed. Specifics of the hormone-dependent regulation, including phosphorylation, traffic, and expression, are considered for particular transporters. Special attention is paid to direct intracellular regulators of the transporter function. The role that dopamine plays as a natriuretic factor in modulating the function of various transporters is described.

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    P. A. Abramicheva & O. V. Smirnova

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Original Russian Text © P.A. Abramicheva, O.V. Smirnova, 2017, published in Fiziologiya Cheloveka, 2017, Vol. 43, No. 4, pp. 134–149.

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Abramicheva, P.A., Smirnova, O.V. Role of hormones in regulating sodium transporters in the kidney: Modulation of phosphorylation, traffic, and expression. Hum Physiol 43, 474–487 (2017). https://doi.org/10.1134/S0362119717040028

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