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Europium-Containing Conjugate for Photodynamic Therapy of Malignant Neoplasms

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Abstract

The rapid growth in the number of oncological diseases justifies the need to create new therapeutic agents and methods. Photodynamic therapy has a wide range of treatments for superficial diseases due to the inability to penetrate more than 3 mm of laser light into tissues. The aim of the study was to characterize the physicochemical properties of a new PEI-E6-DTPA-FA-Eu molecular conjugate based on the europium-modified Сhlorin E6 photosensitizer and to evaluate its phototoxic effect on Ehrlich ascitic tumor cells. It has been established that under 5-minute irradiation with a wavelength of 645 nm and an energy of 6 J/cm2, the synthesized molecular conjugate PEI-E6-DTPA-FA-Eu generates reactive oxygen species 5.1 times more intensively than free Chlorin E6. On the 4th day after photodynamic exposure with PEI-E6-DTPA-FA-Eu, the cell death rate was 75%, while with Chlorin Е6 it was only 24%.

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Funding

The reported study was funded by the Russian Foundation for Basic Research, project no. 20-33-90185.

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Authors and Affiliations

  1. Pacific Institute of Bioorganic Chemistry, G.B. Elyakova Far East Branch of the Russian Academy of Sciences, 690022, Vladivostok, Russia

    O. V. Shevchenko & P. A. Lukyanov

  2. Pacific State Medical University, 690002, Vladivostok, Russia

    O. V. Shevchenko, N. G. Plekhova, K. A. Parichuk & V. I. Apanasevich

  3. Institute of Chemistry, Far East Branch of the Russian Academy of Sciences, 690022, Vladivostok, Russia

    O. V. Shevchenko, M. A. Medkov & A. A. Yudakov

  4. Far Eastern Federal University, Russky Island, 690922, Vladivostok, Russia

    O. V. Shevchenko & I. G. Tananaev

Authors
  1. O. V. Shevchenko
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  2. N. G. Plekhova
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  3. M. A. Medkov
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  4. K. A. Parichuk
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  5. V. I. Apanasevich
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  6. I. G. Tananaev
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  7. A. A. Yudakov
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  8. P. A. Lukyanov
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Correspondence to O. V. Shevchenko.

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Shevchenko, O.V., Plekhova, N.G., Medkov, M.A. et al. Europium-Containing Conjugate for Photodynamic Therapy of Malignant Neoplasms. Russ. J. Inorg. Chem. 67, 1361–1367 (2022). https://doi.org/10.1134/S003602362209011X

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  • DOI: https://doi.org/10.1134/S003602362209011X

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