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Cationic—Anionic Pd(II) Complexes with Adamantylimidazolium Cation: Synthesis, Structural Study, and MAO-Inhibiting Activity

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Abstract

New cationic-anionic palladium(II) complexes have been prepared from adamantyl-substituted imidazolium salts and effect of structure of the adamantyl-substituted salts and synthesis conditions on the structure of these complexes with \({\rm{Pd}}({\rm{DMSO}}){\rm{Hal}}_3^ - \) (1–4), \({\rm{P}}{{\rm{d}}_2}{\rm{Br}}_6^{2 - }\) (5, 6), or \({\rm{PdCl}}_4^{2 - }\) (7) anions has been studied. A number of palladium(II) complexes active against monoamine oxidase B has been prepared, effect of composition and structure on their biological activity have been revealed. The structure of the complexes has been confirmed by X-ray diffraction analysis, a conductometric study of complex 1 has been performed. MAO-inhibiting activity of the obtained complexes has been found to be on the level of reference compounds: 17.6% of residual enzyme activity upon inhibition by complex 3 as compared with 16.9% for reference compound (selegiline). Complexes with bromine ligand show higher activity than those with chlorine ligand. The results of this study can be used in organometallic and bioinorganic chemistry.

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Authors and Affiliations

  1. Institute of Technical Chemistry, Ural Branch, Russian Academy of Sciences, Perm, 614013, Russia

    M. S. Denisov, D. V. Eroshenko & V. A. Glushkov

  2. Perm State University, Perm, 614990, Russia

    M. V. Dmitriev, S. P. Shavkunov & V. A. Glushkov

  3. Ural State Technical University, Yekaterinburg, 620002, Russia

    P. A. Slepukhin

  4. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, Yekaterinburg, 620990, Russia

    P. A. Slepukhin

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  1. M. S. Denisov
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Denisov, M.S., Dmitriev, M.V., Eroshenko, D.V. et al. Cationic—Anionic Pd(II) Complexes with Adamantylimidazolium Cation: Synthesis, Structural Study, and MAO-Inhibiting Activity. Russ. J. Inorg. Chem. 64, 56–67 (2019). https://doi.org/10.1134/S0036023619010054

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