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Association of immune system gene polymorphisms with quantitative traits pathogenetically important for chronic virus hepatitis

  • Genomics. Transcriptomics. Proteomics
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Abstract

The IL4 C(−590)T, IL4RA Ile50Val, and TNF G(−308)A polymorphisms were tested for association with quantitative traits important for chronic virus hepatitis, including the levels of IL4, IL10, IL12, TNF-α, fibronectin, collagenase, the proteinase inhibitor, macroglobulin, and free and protein-bound (PBO) oxyproline. Allele A of the TNF G(−308)A polymorphism was associated with a lower TNF-α production by mononuclear cells, a higher production of IL4 and IL12, and a lower PBO level. The genotype CT of the IL4 C(−590)T polymorphism was associated with a high PBO level.

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Authors and Affiliations

  1. Institute of Medical Genetics, Tomsk Research Center, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, 634050, Russia

    I. A. Goncharova, M. B. Freidin & V. P. Puzyrev

  2. Siberian State Medical University, Tomsk, 634050, Russia

    E. V. Beloborodova, E. I. Beloborodova, G. E. Chernogoruk & V. P. Puzyrev

Authors
  1. I. A. Goncharova
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  2. E. V. Beloborodova
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  3. M. B. Freidin
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  4. E. I. Beloborodova
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  5. G. E. Chernogoruk
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  6. V. P. Puzyrev
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Corresponding author

Correspondence to I. A. Goncharova.

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Original Russian Text © I.A. Goncharova, E.V. Beloborodova, M.B. Freidin, E.I. Beloborodova, G.E. Chernogoruk, V.P. Puzyrev, 2008, published in Molekulyarnaya Biologiya, 2008, Vol. 42, No. 2, pp. 242–246.

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Goncharova, I.A., Beloborodova, E.V., Freidin, M.B. et al. Association of immune system gene polymorphisms with quantitative traits pathogenetically important for chronic virus hepatitis. Mol Biol 42, 213–216 (2008). https://doi.org/10.1134/S0026893308020064

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  • DOI: https://doi.org/10.1134/S0026893308020064

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