Abstract
VARP is a new VPS9 domain-containing protein that acts as a guanine nucleotide exchange factor for small GTPases Rab21 and Rab5, which regulate early endocytosis. The molecular mechanisms regulating the VARP activity and intracellular localization are unknown. By protein interaction cloning in yeasts, multiadaptor proteins of the 4.1 family and RanBP9 were isolated as putative interaction partners of VARP. The interaction with these proteins was assumed to play an important role in the intracellular localization of VARP and its function in early endocytosis.
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Original Russian Text © I.V. Palgova, E.V. Korobko, I.V. Korobko, 2007, published in Molekulyarnaya Biologiya, 2007, Vol. 41, No. 6, pp. 1009–1013.
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Palgova, I.V., Korobko, E.V. & Korobko, I.V. Multiadaptor proteins of the 4.1 family and RanBP9 as potential interaction partners for VARP, a Rab21 GTPase guanine nucleotide exchange factor. Mol Biol 41, 920–923 (2007). https://doi.org/10.1134/S0026893307060088
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DOI: https://doi.org/10.1134/S0026893307060088