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The fungus Penicillium variabile Sopp 1912 isolated from permafrost deposits as a producer of rugulovasines

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Abstract

It has been established that relict fungi Penicillium variabile Sopp can synthesize clavine alkaloids, rugulovasines A and B, which are revealed in this species for the first time. Submerged cultivation of the strain-producer revealed several microcycles of conidia formation. The synthesis of alkaloids was also of a cyclic character. The synchronism of cyclic rugulovasine biosynthesis and conidia formation was revealed. Zinc ions stimulated fungal growth but had a negative effect on the biosynthesis of rugulovasines.

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Authors and Affiliations

  1. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pr. Nauki 5, Pushchino, Moscow oblast, 142290, Russia

    V. P. Zhelifonova, T. V. Antipova, S. M. Ozerskaya, N. E. Ivanushkina & A. G. Kozlovskii

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  1. V. P. Zhelifonova
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  2. T. V. Antipova
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  3. S. M. Ozerskaya
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  4. N. E. Ivanushkina
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  5. A. G. Kozlovskii
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Correspondence to A. G. Kozlovskii.

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Original Russian Text © V.P. Zhelifonova, T.V. Antipova, S.M. Ozerskaya, N.E. Ivanushkina, A.G. Kozlovskii, 2006, published in Mikrobiologiya, 2006, Vol. 75, No. 6, pp. 742–746.

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Zhelifonova, V.P., Antipova, T.V., Ozerskaya, S.M. et al. The fungus Penicillium variabile Sopp 1912 isolated from permafrost deposits as a producer of rugulovasines. Microbiology 75, 644–648 (2006). https://doi.org/10.1134/S002626170606004X

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  • DOI: https://doi.org/10.1134/S002626170606004X

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