Skip to main content
SpringerLink
Log in

SYNTHESIS, CRYSTAL STRUCTURE, ANTI-LUNG CANCER ACTIVITY OF 2-(4-FLUOROPHENYL)-5- (5-IODO-2-METHYLBENZYL)THIOPHENE

  • Published:
Journal of Structural Chemistry Aims and scope Submit manuscript

Abstract

New heterocycle compound 2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene (1), designed using 5-iodo-2-methylbenzoic acid (2) as the starting material is successfully obtained via the multiple synthesis route and finally characterized by IR, 1H NMR, and single crystal X-ray crystallography. In addition, the in vitro anticancer activity of compound 1 on three human lung cancer cells (H20, H2227, and H69) is further determined, which suggests that compound 1 may be a potential anticancer agent.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

REFERENCES

  1. T. Itani and T. Ishihara. Obes. Sci. Pract., 2018, 4, 477.

  2. D. Zhang, H. Q. Zhang, S. Zhao, Z. G. Li, and S. X. Hou. Int. J. Electrochem. Sc., 2019, 14, 4659.

  3. S. Guo, R. Chen, H. Li, T. Zhang, and Y. Liu. Int. J. Softw. Eng. Know., 2019, 29, 139.

  4. A. A. Abdelsameea and S. L. Kabil. N.-S. Arch. Pharmacol., 2018, 391, 945.

  5. J. Su, Z. Sheng, L. Xie, G. Li, and A. X. Liu. IEEE T. Commun., 2019, 67, 2527.

  6. N. Inagaki, S. I. Harashima, and H. Iijima. Expert Opin. Pharmaco., 2018, 19, 895.

  7. D. Matsutani, M. Sakamoto, Y. Kayama, N. Takeda, R. Horiuchi, and K. Utsunomiya. Cardiovasc. Diabetol., 2018, 17, 73.

  8. D. H. Esprit and A. Koratala. Nephrology (Carlton), 2018, 23, 493.

  9. S. L. Kabil and N. M. Mahmoud. Eur. J. Pharmacol., 2018, 828, 135.

  10. G. M. Sheldrick. SHELXL-97, Program for Solution Crystal Structure and Refinement. University of Göttingen, Germany, 1997.

  11. L. Kupcsik. Methods Mol. Biol., 2011, 740, 13.

Download references

Funding

This work was supported by grants from Health and Family Planning Commission of Inner Mongolia Autonomous Region (201703143) and Inner Mongolia Autonomous Region Natural Science Foundation (2018MS08113).

Author information

Authors and Affiliations

  1. The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China

    L P Zhou

  2. The First Clinical Medical of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P. R. China

    F Qiu, C M Wang & J P Liu

  3. Tongliao City Hospital, Tongliao, Inner Mongolia, P. R. China

    Z F Zhang

  4. Zhejiang University School of Medicine, Yiwu, Zhejiang, P. R. China

    Y L Dong

Authors
  1. L P Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F Qiu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Z F Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C M Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Y L Dong
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J P Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J P Liu.

Ethics declarations

The authors declare that they have no conflict of interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhou, L.P., Qiu, F., Zhang, Z.F. et al. SYNTHESIS, CRYSTAL STRUCTURE, ANTI-LUNG CANCER ACTIVITY OF 2-(4-FLUOROPHENYL)-5- (5-IODO-2-METHYLBENZYL)THIOPHENE. J Struct Chem 61, 1111–1116 (2020). https://doi.org/10.1134/S0022476620070148

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0022476620070148

Keywords

Search

Navigation