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The Role of Reactive Oxygen Species in the Regulation of Blood Vessel Tone in Perinatal and Early Postnatal Ontogenesis

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Abstract

Reactive oxygen species (ROS) have been considered for many years as negative regulators in the cardiovascular system. Indeed, excessive production of ROS characterizes many cardiovascular diseases. The damaging effect of ROS can be especially pronounced in a newborn organism, since during this period their vasoconstrictor effect in pulmonary arteries remains as high as in pre-term fetus and the antioxidant systems have not yet formed. Therefore, in the first hours and days of independent life, pulmonary arteries tend to contract, primarily due to the low bioavailability of endothelial NO, which increases the risk of developing pulmonary hypertension in newborns. At the same time, during the perinatal period, ROS play an important role in the adaptive reactions of the circulatory system. ROS provide occlusion of the ductus arteriosus and separation of the pulmonary and systemic circulations soon after birth, and also contribute to the contraction of peripheral vessels during hypoxia, which often accompanies the delivery, and therefore provide priority blood supply to the brain in these conditions. The vasomotor effect of ROS is also pronounced in early postnatal ontogenesis, but it has a different character. In the first weeks of life, the action of ROS serves as one of the mechanisms for increasing endothelium-dependent relaxation of pulmonary vessels. In addition, during early postnatal ontogeny, ROS may play an important role in the regulation of systemic vascular tone. This review outlines the current understanding of the vasomotor role of ROS in the vessels of the pulmonary and systemic circulations and considers the mechanisms of ROS effects on the functioning of vascular endothelial and smooth muscle cells in the perinatal and early postnatal periods.

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Funding

This work was supported by the Russian Science Foundation (project no. 23-25-00056).

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Authors and Affiliations

  1. Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia

    A. A. Shvetsova, D. K. Gaynullina & O. S. Tarasova

  2. Institute of Biomedical Problems RAS, Moscow, Russia

    O. S. Tarasova

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  1. A. A. Shvetsova
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  2. D. K. Gaynullina
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  3. O. S. Tarasova
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A.A.Sh., D.K.G., and O.S.T. conceptualized the review, wrote, read, and approved the submitted version of the text.

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Correspondence to A. A. Shvetsova.

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ETHICS APPROVAL AND CONSENT TO PARTICIPATE

All procedures performed in the study, the results of which are shown in Fig. 3, complied with the ethical standards approved by the legal acts of the Russian Federation, the principles of the Basel Declaration and the recommendations of the Bioethical Commission of Moscow State University (Minutes no. 149-a of April 20, 2023).

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Translated by A. Dyomina

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Russian Text © The Author(s), 2023, published in Rossiiskii Fiziologicheskii Zhurnal imeni I.M. Sechenova, 2023, Vol. 109, No. 12, pp. 1742–1762https://doi.org/10.31857/S0869813923120105.

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Shvetsova, A.A., Gaynullina, D.K. & Tarasova, O.S. The Role of Reactive Oxygen Species in the Regulation of Blood Vessel Tone in Perinatal and Early Postnatal Ontogenesis. J Evol Biochem Phys 59, 2210–2227 (2023). https://doi.org/10.1134/S0022093023060248

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